UniProt Accession

 DHSA_RAT; Q920L2 

Genbank Protein ID

 AB072907 

Genbank Nucleotide ID

 BAB69818.1 

Protein Name

 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 

Protein Synonyms/Alias

 Flavoprotein subunit of complex II; Fp 

Gene Name

 Sdha 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
171	AFGGQSLKFGKGGQA	acetylation	[1]
174	GQSLKFGKGGQAHRC	acetylation	[1]
327	ERYAPVAKDLASRDV	acetylation	[1]
415	NYKGQVLKHVNGQDQ	acetylation	[1]
490	ESVMNLDKLRFADGS	acetylation	[1]
509	ELRLSMQKSMQSHAA	acetylation	[1]
530	VLQEGCEKVSQLYGD	acetylation	[1]
542	YGDLQHLKTFDRGMV	acetylation	[1]
590	AHAREDYKVRIDEYD	acetylation	[1]
600	IDEYDYSKPIEGQQK	acetylation	[1]
608	PIEGQQKKPFAEHWR	acetylation	[1]
625	TLSYVDTKTGKVTLD	acetylation	[1]
628	YVDTKTGKVTLDYRP	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). Can act as a tumor suppressor (By similarity). 

Sequence Annotation

 NP_BIND 60 65 FAD (By similarity).
 NP_BIND 83 98 FAD (By similarity).
 NP_BIND 448 449 FAD (By similarity).
 ACT_SITE 332 332 Proton acceptor (By similarity).
 BINDING 267 267 FAD (By similarity).
 BINDING 288 288 Substrate (By similarity).
 BINDING 300 300 Substrate (By similarity).
 BINDING 399 399 Substrate (By similarity).
 BINDING 432 432 FAD (By similarity).
 BINDING 443 443 Substrate (By similarity).
 MOD_RES 91 91 Tele-8alpha-FAD histidine (By
 MOD_RES 171 171 N6-acetyllysine (By similarity).
 MOD_RES 207 207 Phosphotyrosine; by SRC (By similarity).
 MOD_RES 244 244 Phosphothreonine (By similarity).
 MOD_RES 327 327 N6-acetyllysine (By similarity).
 MOD_RES 415 415 N6-acetyllysine (By similarity).
 MOD_RES 477 477 N6-acetyllysine (By similarity).
 MOD_RES 490 490 N6-acetyllysine (By similarity).
 MOD_RES 530 530 N6-acetyllysine (By similarity).
 MOD_RES 600 600 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Electron transport; FAD; Flavoprotein; Membrane; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Phosphoprotein; Reference proteome; Transit peptide; Transport; Tricarboxylic acid cycle; Tumor suppressor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 656 AA 

Protein Sequence

Gene Ontology

 GO:0005749; C:mitochondrial respiratory chain complex II; ISS:UniProtKB.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0008177; F:succinate dehydrogenase (ubiquinone) activity; IMP:RGD.
 GO:0007399; P:nervous system development; IEA:Compara.
 GO:0022904; P:respiratory electron transport chain; ISS:UniProtKB.
 GO:0006105; P:succinate metabolic process; ISS:UniProtKB.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway. 

Interpro

 IPR003953; FAD_bind_dom.
 IPR003952; FRD_SDH_FAD_BS.
 IPR015939; Fum_Rdtase/Succ_DH_flav-like_C.
 IPR027477; Succ_DH/fumarate_Rdtase_cat.
 IPR011281; Succ_DH_flav_su_fwd.
 IPR014006; Succ_Dhase_FrdA_Gneg. 

Pfam

 PF00890; FAD_binding_2
 PF02910; Succ_DH_flav_C 

SMART

  

PROSITE

 PS00504; FRD_SDH_FAD_BINDING 

PRINTS