CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013882
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 CTP synthase 
Protein Synonyms/Alias
 CTP synthetase; UTP--ammonia ligase 
Gene Name
 pyrG 
Gene Synonyms/Alias
 TTHA1466 
Created Date
 July 27, 2013 
Organism
 Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) 
NCBI Taxa ID
 300852 
Lysine Modification
Position
Peptide
Type
References
462LLHRLYGKEEVLERHacetylation[1]
Reference
 [1] Acetylome with structural mapping reveals the significance of lysine acetylation in Thermus thermophilus.
 Okanishi H, Kim K, Masui R, Kuramitsu S.
 J Proteome Res. 2013 Aug 1;. [PMID: 23901841] 
Functional Description
 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity). 
Sequence Annotation
 DOMAIN 302 549 Glutamine amidotransferase type-1.
 REGION 1 264 Aminator domain.
 ACT_SITE 391 391 Nucleophile (By similarity).
 ACT_SITE 522 522 By similarity.
 ACT_SITE 524 524 By similarity.  
Keyword
 3D-structure; ATP-binding; Complete proteome; Glutamine amidotransferase; Ligase; Nucleotide-binding; Pyrimidine biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 550 AA 
Protein Sequence
MNGSADAGPR PRKYVFITGG VVSSLGKGIL TSSLGALLRA RGYRVTAIKI DPYVNVDAGT 60
MRPYEHGEVF VTADGAETDL DIGHYERFLD MDLSRGNNLT TGQVYLSVIQ KERRGEYLSQ 120
TVQVIPHITD EIKERIRKVA EEQKAEIVVV EVGGTVGDIE SLPFLEAIRQ FRFDEGEGNT 180
LYLHLTLVPY LETSEEFKTK PTQHSVATLR GVGIQPDILV LRSARPVPEE VRRKVALFTN 240
VRPGHVFSSP TVEHLYEVPL LLEEQGLGRA VERALGLEAV IPNLSFWQEA VRVLKHPERT 300
VKIAIAGKYV KMPDAYLSLL EALRHAGIKN RARVEVKWVD AESLEAADLD EAFRDVSGIL 360
VPGGFGVRGI EGKVRAAQYA RERKIPYLGI CLGLQIAVIE FARNVAGLKG ANSTEFDPHT 420
PHPVIDLMPE QLEVEGLGGT MRLGDWPMRI KPGTLLHRLY GKEEVLERHR HRYEVNPLYV 480
DGLERAGLVV SATTPGMRGR GAGLVEAIEL KDHPFFLGLQ SHPEFKSRPM RPSPPFVGFV 540
EAALAYQERA 550 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003883; F:CTP synthase activity; IEA:HAMAP.
 GO:0044210; P:'de novo' CTP biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006541; P:glutamine metabolic process; IEA:HAMAP. 
Interpro
 IPR004468; CTP_synthase.
 IPR017456; CTP_synthase_N.
 IPR017926; GATASE.
 IPR027417; P-loop_NTPase. 
Pfam
 PF06418; CTP_synth_N
 PF00117; GATase 
SMART
  
PROSITE
 PS51273; GATASE_TYPE_1 
PRINTS