CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017698
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Folliculin 
Protein Synonyms/Alias
 BHD skin lesion fibrofolliculoma protein; Birt-Hogg-Dube syndrome protein 
Gene Name
 FLCN 
Gene Synonyms/Alias
 BHD 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
206ELQGKALKVFEAEQFubiquitination[1, 2, 3]
272CGSRLTEKLLEGAPTubiquitination[2]
559FWMTGLSKTYKSHLMubiquitination[1, 3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
 May play a role in the pathogenesis of an uncommon form of kidney cancer through its association with an inherited disorder of the hair follicle (fibrofolliculomas). May be a tumor suppressor. May be involved in colorectal tumorigenesis. May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1. 
Sequence Annotation
 MOD_RES 62 62 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Disease mutation; Nucleus; Phosphoprotein; Reference proteome; Tumor suppressor. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 579 AA 
Protein Sequence
MNAIVALCHF CELHGPRTLF CTEVLHAPLP QGDGNEDSPG QGEQAEEEEG GIQMNSRMRA 60
HSPAEGASVE SSSPGPKKSD MCEGCRSLAA GHPGYISHDK ETSIKYVSHQ HPSHPQLFSI 120
VRQACVRSLS CEVCPGREGP IFFGDEQHGF VFSHTFFIKD SLARGFQRWY SIITIMMDRI 180
YLINSWPFLL GKVRGIIDEL QGKALKVFEA EQFGCPQRAQ RMNTAFTPFL HQRNGNAARS 240
LTSLTSDDNL WACLHTSFAW LLKACGSRLT EKLLEGAPTE DTLVQMEKLA DLEEESESWD 300
NSEAEEEEKA PVLPESTEGR ELTQGPAESS SLSGCGSWQP RKLPVFKSLR HMRQVLGAPS 360
FRMLAWHVLM GNQVIWKSRD VDLVQSAFEV LRTMLPVGCV RIIPYSSQYE EAYRCNFLGL 420
SPHVQIPPHV LSSEFAVIVE VHAAARSTLH PVGCEDDQSL SKYEFVVTSG SPVAADRVGP 480
TILNKIEAAL TNQNLSVDVV DQCLVCLKEE WMNKVKVLFK FTKVDSRPKE DTQKLLSILG 540
ASEEDNVKLL KFWMTGLSKT YKSHLMSTVR SPTASESRN 579 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0032403; F:protein complex binding; IDA:UniProtKB.
 GO:0007043; P:cell-cell junction assembly; ISS:UniProtKB.
 GO:0030097; P:hemopoiesis; ISS:UniProtKB.
 GO:0001701; P:in utero embryonic development; ISS:UniProtKB.
 GO:2001170; P:negative regulation of ATP biosynthetic process; ISS:UniProtKB.
 GO:0030308; P:negative regulation of cell growth; IDA:UniProtKB.
 GO:0030336; P:negative regulation of cell migration; IMP:UniProtKB.
 GO:1901723; P:negative regulation of cell proliferation involved in kidney development; ISS:UniProtKB.
 GO:2000506; P:negative regulation of energy homeostasis; ISS:UniProtKB.
 GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
 GO:0010823; P:negative regulation of mitochondrion organization; ISS:UniProtKB.
 GO:0051898; P:negative regulation of protein kinase B signaling cascade; ISS:UniProtKB.
 GO:1900181; P:negative regulation of protein localization to nucleus; IDA:UniProtKB.
 GO:0035024; P:negative regulation of Rho protein signal transduction; IMP:UniProtKB.
 GO:0032007; P:negative regulation of TOR signaling cascade; ISS:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
 GO:0045785; P:positive regulation of cell adhesion; IMP:UniProtKB.
 GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.
 GO:0032008; P:positive regulation of TOR signaling cascade; ISS:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.
 GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IDA:UniProtKB.
 GO:0032465; P:regulation of cytokinesis; IMP:UniProtKB.
 GO:0035065; P:regulation of histone acetylation; ISS:UniProtKB.
 GO:2000973; P:regulation of pro-B cell differentiation; ISS:UniProtKB.
 GO:0006950; P:response to stress; IMP:UniProtKB.
 GO:0031929; P:TOR signaling cascade; IMP:UniProtKB. 
Interpro
 IPR021713; Folliculin. 
Pfam
 PF11704; Folliculin 
SMART
  
PROSITE
  
PRINTS