CPLM-008881

Genbank Nucleotide ID

Sodium/potassium-transporting ATPase subunit beta-3

Protein Synonyms/Alias

Sodium/potassium-dependent ATPase subunit beta-3; ATPB-3; CD298

Homo sapiens (Human)

Position	Peptide	Type	References
7	*MTKNEKKSLNQSLA	ubiquitination	[1, 2, 3, 4]
17	NQSLAEWKLFIYNPT	ubiquitination	[2]
86	PGLMVFPKPVTALEY	ubiquitination	[2, 5]
111	AGYIEDLKKFLKPYT	ubiquitination	[2, 5, 6]
112	GYIEDLKKFLKPYTL	ubiquitination	[6]
115	EDLKKFLKPYTLEEQ	ubiquitination	[2, 5, 6, 7]
123	PYTLEEQKNLTVCPD	ubiquitination	[6]
182	MNRIIGLKPEGVPRI	ubiquitination	[2, 5, 6, 7]
194	PRIDCVSKNEDIPNV	ubiquitination	[6, 7, 8]
213	HNGMIDLKYFPYYGK	ubiquitination	[2, 5, 8]
220	KYFPYYGKKLHVGYL	ubiquitination	[8]
221	YFPYYGKKLHVGYLQ	ubiquitination	[6]
259	IDGSANLKSQDDRDK	ubiquitination	[2, 5, 6]
266	KSQDDRDKFLGRVMF	ubiquitination	[6]

[1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
[4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
[5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
[6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[7] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
[8] Global identification of modular cullin-RING ligase substrates.
Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]

Functional Description

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known.

REGION 186 279 immunoglobulin-like (By similarity).
CARBOHYD 124 124 N-linked (GlcNAc...) (Potential).
CARBOHYD 240 240 N-linked (GlcNAc...).
DISULFID 128 144 By similarity.
DISULFID 154 170 By similarity.
DISULFID 191 250 By similarity.

Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Ion transport; Membrane; Potassium; Potassium transport; Reference proteome; Signal-anchor; Sodium; Sodium transport; Sodium/potassium transport; Transmembrane; Transmembrane helix; Transport.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0005901; C:caveola; IEA:Compara.
GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
GO:0005890; C:sodium:potassium-exchanging ATPase complex; TAS:ProtInc.
GO:0005391; F:sodium:potassium-exchanging ATPase activity; TAS:ProtInc.
GO:0007596; P:blood coagulation; TAS:Reactome.
GO:0050900; P:leukocyte migration; TAS:Reactome.

IPR000402; Na/K_ATPase_sub_beta.

PF00287; Na_K-ATPase

PS00390; ATPASE_NA_K_BETA_1