UniProt Accession

 H2AV_TETTS; P08992 

Genbank Protein ID

 X15548; GG662793; X06725 

Genbank Nucleotide ID

 CAA33554.1; EAR90860.2; CAA29903.1 

Protein Name

 Histone H2A.Z 

Protein Synonyms/Alias

 hv1 

Gene Name

 HTA3 

Gene Synonyms/Alias

 HV1; TTHERM_00143660 

Created Date

 July 27, 2013 

Organism

 Tetrahymena thermophila (strain SB210) 

NCBI Taxa ID

 312017 

Lysine Modification

Position	Peptide	Type	References
5	***MAGGKGGKGGKG	acetylation	[1]
8	MAGGKGGKGGKGGKG	acetylation	[1]
11	GKGGKGGKGGKGGKV	acetylation	[1]
14	GKGGKGGKGGKVGGA	acetylation	[1]
17	GKGGKGGKVGGAKNK	acetylation	[1]
22	GGKVGGAKNKKTPQS	acetylation	[1]

Reference

 [1] hv1 is an evolutionarily conserved H2A variant that is preferentially associated with active genes.
 Allis CD, Richman R, Gorovsky MA, Ziegler YS, Touchstone B, Bradley WA, Cook RG.
 J Biol Chem. 1986 Feb 5;261(4):1941-8. [PMID: 3944120] 

Functional Description

 Variant histone H2A which replaces conventional H2A in a subset of nucleosomes, preferentially in transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Essential for vegetative growth. 

Sequence Annotation

 MOD_RES 5 5 N6-acetyllysine.
 MOD_RES 8 8 N6-acetyllysine.
 MOD_RES 11 11 N6-acetyllysine.
 MOD_RES 14 14 N6-acetyllysine.
 MOD_RES 17 17 N6-acetyllysine.
 MOD_RES 22 22 N6-acetyllysine.  

Keyword

 Acetylation; Chromosome; Complete proteome; Direct protein sequencing; DNA-binding; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 146 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0006334; P:nucleosome assembly; IEA:InterPro. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR002119; Histone_H2A. 

Pfam

 PF00125; Histone 

SMART

 SM00414; H2A 

PROSITE

 PS00046; HISTONE_H2A 

PRINTS

 PR00620; HISTONEH2A.