UniProt Accession

 Q9N6D8_DROME; Q9N6D8; Q9VCR8 

Genbank Protein ID

 AF224713; AF224714; AE014297; AF244918; AF250918; AF263722; AY069096; AF192555; AE014297 

Genbank Nucleotide ID

 AAF40427.1; AAF40428.1; AAF56087.2; AAF61572.1; AAF74277.1; AAF75270.1; AAL39241.1; AAL56639.1; ACZ94989.1 

Protein Name

 GH11591p 

Protein Synonyms/Alias

 P53 tumor suppressor-like protein; P53-like regulator of apoptosis and cell cycle; Transcription factor; Transcription factor p53; p53, isoform A; p53, isoform C 

Gene Name

 p53 

Gene Synonyms/Alias

 prac; CG33336; Dmel_CG33336 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
26	DSTEVDIKEDIPKTV	sumoylation	[1]
302	VRRCIAIKTEDTESN	sumoylation	[1]

Reference

 [1] Modification of Drosophila p53 by SUMO modulates its transactivation and pro-apoptotic functions.
 Mauri F, McNamee LM, Lunardi A, Chiacchiera F, Del Sal G, Brodsky MH, Collavin L.
 J Biol Chem. 2008 Jul 25;283(30):20848-56. [PMID: 18492669] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 385 AA 

Protein Sequence

Gene Ontology

 GO:0000785; C:chromatin; IBA:RefGenome.
 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0005667; C:transcription factor complex; IBA:RefGenome.
 GO:0003682; F:chromatin binding; IBA:RefGenome.
 GO:0003684; F:damaged DNA binding; IBA:RefGenome.
 GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.
 GO:0002039; F:p53 binding; IBA:RefGenome.
 GO:0043565; F:sequence-specific DNA binding; IBA:RefGenome.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
 GO:0044212; F:transcription regulatory region DNA binding; IEA:InterPro.
 GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:FlyBase.
 GO:0034644; P:cellular response to UV; IBA:RefGenome.
 GO:0008340; P:determination of adult lifespan; IMP:BHF-UCL.
 GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IBA:RefGenome.
 GO:0035234; P:germ cell programmed cell death; IMP:FlyBase.
 GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IMP:FlyBase.
 GO:0031571; P:mitotic G1 DNA damage checkpoint; IBA:RefGenome.
 GO:0043553; P:negative regulation of phosphatidylinositol 3-kinase activity; IMP:BHF-UCL.
 GO:0046533; P:negative regulation of photoreceptor cell differentiation; IMP:FlyBase.
 GO:0042992; P:negative regulation of transcription factor import into nucleus; IMP:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.
 GO:0014016; P:neuroblast differentiation; IMP:FlyBase.
 GO:0007405; P:neuroblast proliferation; IMP:FlyBase.
 GO:0048477; P:oogenesis; IGI:FlyBase.
 GO:0045787; P:positive regulation of cell cycle; IGI:FlyBase.
 GO:0040010; P:positive regulation of growth rate; IMP:BHF-UCL.
 GO:0043568; P:positive regulation of insulin-like growth factor receptor signaling pathway; IMP:BHF-UCL.
 GO:0040018; P:positive regulation of multicellular organism growth; IMP:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
 GO:0007131; P:reciprocal meiotic recombination; IMP:FlyBase.
 GO:0042127; P:regulation of cell proliferation; IMP:FlyBase.
 GO:0043523; P:regulation of neuron apoptotic process; IBA:RefGenome.
 GO:0046620; P:regulation of organ growth; IMP:FlyBase.
 GO:0010332; P:response to gamma radiation; IBA:RefGenome.
 GO:0010165; P:response to X-ray; IBA:RefGenome.
 GO:0042246; P:tissue regeneration; IMP:FlyBase. 

Interpro

 IPR008967; p53-like_TF_DNA-bd.
 IPR012346; p53/RUNT-type_TF_DNA-bd.
 IPR024631; p53_C_Drosophila.
 IPR011615; p53_DNA-bd.
 IPR002117; p53_tumour_suppressor. 

Pfam

 PF00870; P53
 PF11619; P53_C 

SMART

  

PROSITE

  

PRINTS