| Tag | Content |
|---|
| CPLM ID | CPLM-004935 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | CCA tRNA nucleotidyltransferase, mitochondrial |
Protein Synonyms/Alias | CCA-adding enzyme; tRNA CCA-pyrophosphorylase; tRNA adenylyltransferase; tRNA nucleotidyltransferase |
Gene Name | CCA1 |
Gene Synonyms/Alias | TNT1; YER168C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 150 | FVNLRSEKYTELSRI | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | This enzyme carries out synthesis of the tRNA CCA terminus without the direction of a template using the multiple accepting and donating subsites within its active site. |
Sequence Annotation | |
Keyword | Alternative initiation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Mitochondrion; Nucleotide-binding; Nucleotidyltransferase; Nucleus; Reference proteome; RNA-binding; Transferase; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 546 AA |
Protein Sequence | MLRSTISLLM NSAAQKTMTN SNFVLNAPKI TLTKVEQNIC NLLNDYTDLY NQKYHNKPEP 60
LTLRITGGWV RDKLLGQGSH DLDIAINVMS GEQFATGLNE YLQQHYAKYG AKPHNIHKID 120
KNPEKSKHLE TATTKLFGVE VDFVNLRSEK YTELSRIPKV CFGTPEEDAL RRDATLNALF 180
YNIHKGEVED FTKRGLQDLK DGVLRTPLPA KQTFLDDPLR VLRLIRFASR FNFTIDPEVM 240
AEMGDPQINV AFNSKISRER VGVEMEKILV GPTPLLALQL IQRAHLENVI FFWHNDSSVV 300
KFNEENCQDM DKINHVYNDN ILNSHLKSFI ELYPMFLEKL PILREKIGRS PGFQQNFILS 360
AILSPMANLQ IIGNPKKKIN NLVSVTESIV KEGLKLSKND AAVIAKTVDS ICSYEEILAK 420
FADRSQLKKS EIGIFLRNFN GEWETAHFAS LSDAFLKIPK LETKKIELLF QNYNEFYSYI 480
FDNNLNNCHE LKPIVDGKQM AKLLQMKPGP WLGKINNEAI RWQFDNPTGT DQELITHLKA 540
ILPKYL 546 |
Gene Ontology | GO:0005759; C:mitochondrial matrix; IDA:SGD. GO:0005634; C:nucleus; NAS:SGD. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0052929; F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity; IEA:EC. GO:0052928; F:CTP:3'-cytidine-tRNA cytidylyltransferase activity; IEA:EC. GO:0052927; F:CTP:tRNA cytidylyltransferase activity; IEA:EC. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0004810; F:tRNA adenylyltransferase activity; IDA:SGD. GO:0001680; P:tRNA 3'-terminal CCA addition; IDA:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |