CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029580
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Receptor-interacting serine-threonine kinase 3 
Protein Synonyms/Alias
 Receptor-interacting serine-threonine kinase 3, isoform CRA_a; Receptor-interacting serine/threonine-protein kinase 3 
Gene Name
 Ripk3 
Gene Synonyms/Alias
 rCG_23359 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
466QPRTAFPKKEPAQFGacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Receptor; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 478 AA 
Protein Sequence
MSSVKLWLNG ASSISLVGSE ELENLGFVGK GGFGAVFRAR HTAWNLDVAV KIVNSKKISR 60
EVKAMVNLRH ENVLLLLGVT ENLEWDYVYG PALVTGFMEN GSLSGLLQPS CPRPWPLLCR 120
LLEEVVLGMC YLHSLNPSLL HRDLKPSNVL LDPELHAKLA DFGLSTFQGG SQSGSGSGSR 180
DSGGTLAYLA PELLDNDGKA SKASDVYSFG VLVWTVLAGR EAEVVDKTSL IRGAVCNRQR 240
RPPLTELPPD SPETPGLEGL KELMTHCWSS EPKDRPSFQD CESKTNNVYI LVQDKVDAAV 300
SKVKHYLSQY RSSDTKLSAR ESSQKGTEVD CPRETIVYEM LDRLHLEEPS GSVPERLTSL 360
TERRGKEASF GHATPAGTSS DTLAGTPQIP HTLPSRGTTP RPAFTETPGP DPQRNQGDGR 420
NSNPWYTWNA PNPMTGLQSI VLNNCSEVQI GQHNCMSVQP RTAFPKKEPA QFGRGRGW 478 
Gene Ontology
 GO:0005622; C:intracellular; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004704; F:NF-kappaB-inducing kinase activity; IEA:Compara.
 GO:0032147; P:activation of protein kinase activity; IEA:Compara.
 GO:0007249; P:I-kappaB kinase/NF-kappaB cascade; IEA:Compara.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0060545; P:positive regulation of necroptosis; IEA:Compara.
 GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IEA:Compara.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IEA:Compara. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR025735; RHIM_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase
 PF12721; RHIM 
SMART
  
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS