UniProt Accession

 DCXR_RAT; Q920P0 

Genbank Protein ID

 AB061719 

Genbank Nucleotide ID

 BAB64340.1 

Protein Name

 L-xylulose reductase 

Protein Synonyms/Alias

 XR; Dicarbonyl/L-xylulose reductase 

Gene Name

 Dcxr 

Gene Synonyms/Alias

 Glb 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
171	ALELGPHKIRVNAVN	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L- xylulose. Participates in the uronate cycle of glucose metabolism. May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules. 

Sequence Annotation

 NP_BIND 11 39 NADP (By similarity).
 ACT_SITE 149 149 Proton acceptor.
 ACT_SITE 153 153
 BINDING 136 136 Substrate (By similarity).
 MOD_RES 1 1 N-acetylmethionine (By similarity).  

Keyword

 Acetylation; Carbohydrate metabolism; Complete proteome; Glucose metabolism; Membrane; NADP; Oxidoreductase; Reference proteome; Xylose metabolism. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 244 AA 

Protein Sequence

Gene Ontology

 GO:0005903; C:brush border; IEA:Compara.
 GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB.
 GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
 GO:0005902; C:microvillus; IEA:Compara.
 GO:0050038; F:L-xylulose reductase (NADP+) activity; IDA:UniProtKB.
 GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; IEA:Compara.
 GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-KW.
 GO:0006006; P:glucose metabolic process; IDA:UniProtKB.
 GO:0006739; P:NADP metabolic process; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IDA:UniProtKB.
 GO:0005997; P:xylulose metabolic process; IDA:UniProtKB. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

  

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.