| Tag | Content |
|---|
| CPLM ID | CPLM-021194 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Phospholysine phosphohistidine inorganic pyrophosphate phosphatase |
Protein Synonyms/Alias | hLHPP |
Gene Name | LHPP |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 189 | IKAEVVGKPSPEFFK | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Phosphatase that hydrolyzes imidodiphosphate, 3- phosphohistidine and 6-phospholysine. Has broad substrate specificity and can also hydrolyze inorganic diphosphate, but with lower efficiency (By similarity). |
Sequence Annotation | REGION 17 19 Substrate binding.
REGION 54 55 Substrate binding.
METAL 17 17 Magnesium.
METAL 19 19 Magnesium; via carbonyl oxygen.
METAL 214 214 Magnesium.
BINDING 189 189 Substrate. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Hydrolase; Magnesium; Metal-binding; Nucleus; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 270 AA |
Protein Sequence | MAPWGKRLAG VRGVLLDISG VLYDSGAGGG TAIAGSVEAV ARLKRSRLKV RFCTNESQKS 60
RAELVGQLQR LGFDISEQEV TAPAPAACQI LKEQGLRPYL LIHDGVRSEF DQIDTSNPNC 120
VVIADAGESF SYQNMNNAFQ VLMELEKPVL ISLGKGRYYK ETSGLMLDVG PYMKALEYAC 180
GIKAEVVGKP SPEFFKSALQ AIGVEAHQAV MIGDDIVGDV GGAQRCGMRA LQVRTGKFRP 240
SDEHHPEVKA DGYVDNLAEA VDLLLQHADK 270 |
Gene Ontology | GO:0005829; C:cytosol; IDA:UniProtKB. GO:0005634; C:nucleus; IDA:UniProtKB. GO:0004427; F:inorganic diphosphatase activity; IDA:UniProtKB. GO:0000287; F:magnesium ion binding; ISS:UniProtKB. GO:0008969; F:phosphohistidine phosphatase activity; ISS:UniProtKB. GO:0006470; P:protein dephosphorylation; ISS:UniProtKB. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |