CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036715
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Brefeldin A-inhibited guanine nucleotide-exchange protein 1 
Protein Synonyms/Alias
  
Gene Name
 ARFGEF1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
62LSMKFLEKGELANFRubiquitination[1, 2]
72LANFRFQKDFLRPFEubiquitination[2]
532LESHRFAKAFNSNNEubiquitination[2]
546EQRTALWKAGFKGKSubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 702 AA 
Protein Sequence
MFSLQKIVEI SYYNMGRIRL QWSRIWEVIG DHFNKVGCNP NEDVAIFAVD SLRQLSMKFL 60
EKGELANFRF QKDFLRPFEH IMKRNRSPTI RDMVVRCIAQ MVNSQAANIR SGWKNIFSVF 120
HLAASDQDES IVELAFQTTG HIVTLVFEKH FPATIDSFQD AVKCLSEFAC NAAFPDTSME 180
AIRLIRHCAK YVSDRPQAFK EYTSDDMNVA PEDRVWVRGW FPILFELSCI INRCKLDVRT 240
RGLTVMFEIM KTYGHTYEKH WWQDLFRIVF RIFDNMKLPE QQTEKAEWMT TTCNHALYAI 300
CDVFTQYLEV LSDVLLDDIF AQLYWCVQQD NEQLARSGTN CLENVVILNG EKFTLEIWDK 360
TCNCTLDIFK TTIPHALLTW RPNSGETAPP PPSPVSEKPL DTISQKSVDI HDSIQPRSVD 420
NRPQAPLVSA SAVNEEVSKI KSTAKFPEQK LFAALLIKCV VQLELIQTID NIVFFPATSK 480
KEDAENLAAA QRDAVDFDVR VDTQDQGMYR FLTSQQLFKL LDCLLESHRF AKAFNSNNEQ 540
RTALWKAGFK GKSKPNLLKQ ETSSLACGLR ILFRMYMDES RVSAWEEVQQ RLLNVCSEAL 600
SYFLTLTSES HREAWTNLLL LFLTKVLKIS DNRVSMRLRI QPHISSPIRI GMRGPRAAVQ 660
ELSEMNQAVP RLHCCLCKAT SGLAVSSSVL AFLPPYPALF TN 702 
Gene Ontology
  
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR015403; DUF1981_SEC7_assoc. 
Pfam
 PF09324; DUF1981 
SMART
  
PROSITE
  
PRINTS