UniProt Accession

 C9JKI3_HUMAN; C9JKI3 

Genbank Protein ID

 AC006159 

Genbank Nucleotide ID

  

Protein Name

 Caveolin 

Protein Synonyms/Alias

  

Gene Name

 CAV1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
8	MADELSEKQVYDAHT	acetylation	[1]
8	MADELSEKQVYDAHT	ubiquitination	[2, 3, 4]
16	QVYDAHTKEIDLVNR	ubiquitination	[3, 5]
26	DLVNRDPKHLNDDVV	ubiquitination	[2, 5]
34	HLNDDVVKIDFEDVI	ubiquitination	[4]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). 

Sequence Annotation

  

Keyword

 Cell membrane; Complete proteome; Golgi apparatus; Membrane; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 138 AA 

Protein Sequence

Gene Ontology

 GO:0002080; C:acrosomal membrane; IEA:Compara.
 GO:0005901; C:caveola; IEA:UniProtKB-SubCell.
 GO:0005938; C:cell cortex; IEA:Compara.
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0005887; C:integral to plasma membrane; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0016504; F:peptidase activator activity; IEA:Compara.
 GO:0001525; P:angiogenesis; IEA:Compara.
 GO:0006816; P:calcium ion transport; IEA:Compara.
 GO:0070836; P:caveola assembly; IEA:Compara.
 GO:0006874; P:cellular calcium ion homeostasis; IEA:Compara.
 GO:0042632; P:cholesterol homeostasis; IEA:Compara.
 GO:0000188; P:inactivation of MAPK activity; IEA:Compara.
 GO:0007595; P:lactation; IEA:Compara.
 GO:0019915; P:lipid storage; IEA:Compara.
 GO:0060056; P:mammary gland involution; IEA:Compara.
 GO:0000165; P:MAPK cascade; IEA:Compara.
 GO:0051899; P:membrane depolarization; IEA:Compara.
 GO:2000811; P:negative regulation of anoikis; IEA:Compara.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IEA:Compara.
 GO:0001937; P:negative regulation of endothelial cell proliferation; IEA:Compara.
 GO:0030857; P:negative regulation of epithelial cell differentiation; IEA:Compara.
 GO:0045019; P:negative regulation of nitric oxide biosynthetic process; IEA:Compara.
 GO:0051001; P:negative regulation of nitric-oxide synthase activity; IEA:Compara.
 GO:0031397; P:negative regulation of protein ubiquitination; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0042524; P:negative regulation of tyrosine phosphorylation of Stat5 protein; IEA:Compara.
 GO:0033484; P:nitric oxide homeostasis; IEA:Compara.
 GO:0010524; P:positive regulation of calcium ion transport into cytosol; IEA:Compara.
 GO:0048554; P:positive regulation of metalloenzyme activity; IEA:Compara.
 GO:0045907; P:positive regulation of vasoconstriction; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IEA:Compara.
 GO:0008104; P:protein localization; IEA:Compara.
 GO:0019217; P:regulation of fatty acid metabolic process; IEA:Compara.
 GO:0006940; P:regulation of smooth muscle contraction; IEA:Compara.
 GO:0003057; P:regulation of the force of heart contraction by chemical signal; IEA:Compara.
 GO:0051592; P:response to calcium ion; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara.
 GO:0001666; P:response to hypoxia; IEA:Compara.
 GO:0002931; P:response to ischemia; IEA:Compara.
 GO:0007519; P:skeletal muscle tissue development; IEA:Compara.
 GO:0006641; P:triglyceride metabolic process; IEA:Compara.
 GO:0001570; P:vasculogenesis; IEA:Compara.
 GO:0042310; P:vasoconstriction; IEA:Compara. 

Interpro

 IPR001612; Caveolin.
 IPR015504; Caveolin_1.
 IPR018361; Caveolin_CS. 

Pfam

 PF01146; Caveolin 

SMART

  

PROSITE

 PS01210; CAVEOLIN 

PRINTS