| Tag | Content |
|---|
| CPLM ID | CPLM-016552 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Disheveled-associated activator of morphogenesis 1 |
Protein Synonyms/Alias | |
Gene Name | Daam1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 779 | RLQSLYFKKKFAERV | ubiquitination | [1] | | 903 | STLRSGLKAVETELE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Binds to disheveled (Dvl) and Rho, and mediates Wnt- induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments (By similarity). |
Sequence Annotation | DOMAIN 45 420 GBD/FH3.
DOMAIN 528 599 FH1.
DOMAIN 600 1008 FH2.
DOMAIN 1026 1057 DAD.
REGION 693 702 Actin-binding (By similarity). |
Keyword | Actin-binding; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1077 AA |
Protein Sequence | MAPRKRGGRG ISFIFCCFRN NDHPEITYRL RNDSNFALQT MEPALPMPPV EELDVMFSEL 60
VDELDLTDKH REAMFALPAE KKWQIYCSKK KDQEENKGAT SWPEFYIDQL NSMAARKSLL 120
ALEKEEEEER SKTIESLKTA LRTKPMRFVT RFIDLDGLSC ILNFLKTMDY ETSESRIHTS 180
LIGCIKALMN NSQGRAHVLA HSESINVIAQ SLSTENIKTK VAVLEILGAV CLVPGGHKKV 240
LQAMLHYQKY ASERTRFQTL INDLDKSTGR YRDEVSLKTA IMSFINAVLS QGAGVESLDF 300
RLHLRYEFLM LGIQPVIDKL REHENSTLDR HLDFFEMLRN EDELEFAKRF ELVHIDTKSA 360
TQMFELTRRR LTHSEAYPHF MSILHHCLQM PYKRSGNTVQ YWLLLDRIIQ QIVIQNDKGQ 420
DPDSTPLENF NIKNVVRMLV NENEVKQWKE QAEKMRKEHN ELQQKLEKKE RECDAKTQEK 480
EEMMQTLNKM KEKLEKETTE HKQVKQQVAD LTAQLHELNR RAVCAAVPGG PSPGAPGGPF 540
PSSGLGSLLP PPPPPLLSGG ALPPPPPPLP PGGPPPPPGP PPLGGVLPPP GAPVSLTLKK 600
KNIPQPTNAL KSFNWSKLPE NKLDGTVWTE IDDTKVFKIL DLEDLERTFS AYQRQQEFFV 660
NNSKQKEADA IDDTLSSKLK VKELSVIDGR RAQNCNILLS RLKLSNDEIK RAILTMDEQE 720
DLPKDMLEQL LKFVPEKSDI DLLEEHKHEL DRMAKADRFL FEMSRINHYQ QRLQSLYFKK 780
KFAERVAEVK PKVEAIRSGS EEVFRSRALK QLLEVVLAFG NYMNKGQRGN AYGFKISSLN 840
KIADTKSSID KNITLLHYLI TIVENKYPKV LNLSEELRDI PQAAKVNMTE LDKEISTLRS 900
GLKAVETELE YQKSQPPQPG DKFVSVVSQF ITLASFSFSD VEDLLAEAKE LFTKAVKHFG 960
EEAGKIQPDE FFGIFDQFLQ AVAEAKQENE NMRKRKEEEE RRARLEAQLK EQRERERKVR 1020
KAKESSEESG EFDDLVSALR SGEVFDKDLS KLKRNRKRIS NQVTDSSRER PITKLNF 1077 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |