CPLM-020288

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-020288

UniProt Accession

CHID1_HUMAN; Q9BWS9; B3KWB0; Q8NBM9; Q96CZ3; Q96S93; Q96SK0; Q9BY52

Genbank Protein ID

BN000479; AF212229; AY037151; AK027711; AK075413; AK124697; BC000001; BC013642; BC095409

Genbank Nucleotide ID

CAF32458.1; AAK14915.1; AAK67632.1; BAB55316.1; BAC11603.1; BAG54072.1; AAH00001.1; AAH13642.1; AAH95409.1

Protein Name

Chitinase domain-containing protein 1

Protein Synonyms/Alias

Stabilin-1-interacting chitinase-like protein; SI-CLP

Gene Name

CHID1

Gene Synonyms/Alias

GL008; PSEC0104; SB139

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
37	ASKTLLEKSQFSDKP	ubiquitination	[1]

Reference

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]

Functional Description

Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro).

Sequence Annotation

Keyword

3D-structure; Alternative splicing; Complete proteome; Immunity; Innate immunity; Lysosome; Polymorphism; Reference proteome; Secreted; Signal.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

393 AA

Protein Sequence

MRTLFNLLWL ALACSPVHTT LSKSDAKKAA SKTLLEKSQF SDKPVQDRGL VVTDLKAESV 60
VLEHRSYCSA KARDRHFAGD VLGYVTPWNS HGYDVTKVFG SKFTQISPVW LQLKRRGREM 120
FEVTGLHDVD QGWMRAVRKH AKGLHIVPRL LFEDWTYDDF RNVLDSEDEI EELSKTVVQV 180
AKNQHFDGFV VEVWNQLLSQ KRVGLIHMLT HLAEALHQAR LLALLVIPPA ITPGTDQLGM 240
FTHKEFEQLA PVLDGFSLMT YDYSTAHQPG PNAPLSWVRA CVQVLDPKSK WRSKILLGLN 300
FYGMDYATSK DAREPVVGAR YIQTLKDHRP RMVWDSQASE HFFEYKKSRS GRHVVFYPTL 360
KSLQVRLELA RELGVGVSIW ELGQGLDYFY DLL 393

Gene Ontology

GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
GO:0004568; F:chitinase activity; IEA:InterPro.
GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
GO:0006032; P:chitin catabolic process; IEA:InterPro.
GO:0045087; P:innate immune response; IEA:UniProtKB-KW.

Interpro

IPR011583; Chitinase_II.
IPR001223; Glyco_hydro18cat.
IPR013781; Glyco_hydro_catalytic_dom.
IPR017853; Glycoside_hydrolase_SF.

Pfam

PF00704; Glyco_hydro_18

SMART

SM00636; Glyco_18

PROSITE

PS01095; CHITINASE_18

PRINTS