| Tag | Content |
|---|
| CPLM ID | CPLM-018389 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Histone H2A |
Protein Synonyms/Alias | |
Gene Name | hh2a |
Gene Synonyms/Alias | hta-1; NCU02437 |
Created Date | July 27, 2013 |
Organism | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DS |
NCBI Taxa ID | 367110 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 10 | GGGKSGGKASGSKNA | acetylation | [1] |
|
Reference | [1] Mapping of lysine methylation and acetylation in core histones of Neurospora crassa. Xiong L, Adhvaryu KK, Selker EU, Wang Y. Biochemistry. 2010 Jun 29;49(25):5236-43. [ PMID: 20433192] |
Functional Description | Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
Sequence Annotation | MOTIF 131 132 [ST]-Q motif.
MOD_RES 6 6 N6-acetyllysine (By similarity).
MOD_RES 10 10 N6-acetyllysine (By similarity).
MOD_RES 131 131 Phosphoserine (By similarity). |
Keyword | Acetylation; Chromosome; Complete proteome; DNA damage; DNA repair; DNA-binding; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 134 AA |
Protein Sequence | MTGGGKSGGK ASGSKNAQSR SSKAGLAFPV GRVHRLLRKG NYAQRVGAGA PVYLAAVLEY 60
LAAEILELAG NAARDNKKTR IIPRHLQLAI RNDEELNKLL GHVTIAQGGV LPNIHQNLLP 120
KKTGKTGKNA SQEL 134 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |