CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017237
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dimethylaniline monooxygenase [N-oxide-forming] 2 
Protein Synonyms/Alias
 Dimethylaniline oxidase 2; Pulmonary flavin-containing monooxygenase 2; FMO 2 
Gene Name
 Fmo2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
44IGGLWRFKENVEDGRubiquitination[1]
276YGLVPQNKYLMKEPVubiquitination[1]
280PQNKYLMKEPVLNDDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Shows catalytic activity towards methimazole, thiourea, trimethylamine, and the insecticide phorate. 
Sequence Annotation
 NP_BIND 9 14 FAD (Potential).
 NP_BIND 191 196 NADP (Potential).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 CROSSLNK 492 492 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 Acetylation; Complete proteome; Endoplasmic reticulum; FAD; Flavoprotein; Isopeptide bond; Magnesium; Membrane; Microsome; Monooxygenase; NADP; Oxidoreductase; Reference proteome; Transmembrane; Ubl conjugation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 535 AA 
Protein Sequence
MAKKVVVIGA GVSGLISLKC CVDEGLEPTC FERTEDIGGL WRFKENVEDG RASIYRSVIT 60
NTSKEMSCFS DFPMPEDFPN FLHNSKLLEY FRIFAKKFDL LKYIQFQTTV ISVKKRPDFA 120
SSGQWEVYTQ SNGKEQRTVF DAVMVCSGHH IQPHLPLKSF PGIERFRGQY FHSREYKHPV 180
GFEGKRILVV GIGNSAADIA SELSKTAAQV FVSTRHGSWV MSRISEDGYP WDMVFHTRFS 240
SMLRNVLPRT VVKWMMEQQM NRWFNHENYG LVPQNKYLMK EPVLNDDLPS RLLYGAIKVK 300
TRVKELTETA VVFEDGTVEE DVDIIVFATG YTFSFSFLED SLVKVEDNRV SLYKAMFPPH 360
LEKPTLACIG LIQPLGSIFP TVELQARWAT RVFKGLCSLP SETTMMADIV ERNEKRVNLF 420
GKSQSQILQT NYVDYLDELA LEIGAKPDFV SLFFKDPKLA VKLYFGPCNS YQYRLVGPGQ 480
WEGARNAILT QKQRILKPLK TRTLQSSDSA PVSFLLKILG LLAVVLAFFF QLQGF 535 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031227; C:intrinsic to endoplasmic reticulum membrane; IEA:InterPro.
 GO:0016020; C:membrane; ISS:UniProtKB.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0004497; F:monooxygenase activity; IDA:MGI.
 GO:0004499; F:N,N-dimethylaniline monooxygenase activity; IEA:EC.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0017144; P:drug metabolic process; IEA:Compara.
 GO:0070995; P:NADPH oxidation; ISS:UniProtKB.
 GO:0006082; P:organic acid metabolic process; IEA:Compara.
 GO:0072592; P:oxygen metabolic process; IDA:MGI.
 GO:0009404; P:toxin metabolic process; IEA:Compara.
 GO:0006805; P:xenobiotic metabolic process; IEA:Compara. 
Interpro
 IPR012143; DiMe-aniline_mOase.
 IPR000960; Flavin_mOase.
 IPR020946; Flavin_mOase-like.
 IPR002254; Flavin_mOase_2.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF00743; FMO-like 
SMART
  
PROSITE
  
PRINTS
 PR00370; FMOXYGENASE.
 PR01122; FMOXYGENASE2.