CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023309
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
 AAA19585.1; AAA19594.1; AAA19595.1; AAC72083.1; AAC72084.1; AAC72085.1; AAC72086.1; AAC72087.1; AAC72088.1; AAC72089.1; AAC72090.1; AAC72091.1; AAC72092.1; AAC72093.1; AAC72094.1; AAC95297.1; AAC95297.1; AAC95297.1; AAC95297.1; AAC95297.1; AAC95297.1; AAC95297.1; AAC95297.1; AAC95297.1; AAC95297.1; AAC95297.1; AAC95297.1; AAC95298.1; AAC95298.1; AAC95298.1; AAC95298.1; AAC95298.1; AAC95298.1; AAC95298.1; AAC95298.1; AAC95298.1; AAC95298.1; AAC95298.1; AAC95298.1; AAC95299.1; AAC95299.1; AAC95299.1; AAC95299.1; AAC95299.1; AAC95299.1; AAC95299.1; AAC95299.1; AAC95299.1; AAC95299.1; AAC95299.1; AAC95299.1; AAC95300.1; AAC95300.1; AAC95300.1; AAC95300.1; AAC95300.1; AAC95300.1; AAC95300.1; AAC95300.1; AAC95300.1; AAC95300.1; AAC95300.1; AAC95300.1; AAC95302.1; AAC95302.1; AAC95302.1; AAC95302.1; AAC95303.1; AAC95303.1; AAC95303.1; AAC95303.1; CAI20032.1; CAI20033.1; CAI20034.1; AAI10906.1 
Protein Name
 Cyclin-dependent kinase 11A 
Protein Synonyms/Alias
 Cell division cycle 2-like protein kinase 2; Cell division protein kinase 11A; Galactosyltransferase-associated protein kinase p58/GTA; PITSLRE serine/threonine-protein kinase CDC2L2 
Gene Name
 CDK11A 
Gene Synonyms/Alias
 CDC2L2; CDC2L3; PITSLREB 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
20LDEILQEKKRRKEQEubiquitination[1]
455TDEIVALKRLKMEKEubiquitination[1]
565LSHAGILKVGDFGLAubiquitination[1]
648ELGTPSEKIWPGYSEubiquitination[1, 2]
660YSELPVVKKMTFSEHubiquitination[2]
661SELPVVKKMTFSEHPubiquitination[2]
707ISAEDGLKHEYFRETubiquitination[1]
729MFPTWPAKSEQQRVKubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Appears to play multiple roles in cell cycle progression, cytokinesis and apoptosis. The p110 isoforms have been suggested to be involved in pre-mRNA splicing, potentially by phosphorylating the splicing protein SFRS7. The p58 isoform may act as a negative regulator of normal cell cycle progression. 
Sequence Annotation
 DOMAIN 427 647 Protein kinase.
 NP_BIND 432 440 ATP (By similarity).
 ACT_SITE 550 550 Proton acceptor (By similarity).
 BINDING 455 455 ATP (By similarity).
 MOD_RES 47 47 Phosphoserine (By similarity).
 MOD_RES 265 265 Phosphoserine (By similarity).
 MOD_RES 271 271 Phosphoserine (By similarity).
 MOD_RES 470 470 Phosphoserine; by CDK7 (By similarity).
 MOD_RES 476 476 Phosphothreonine; by CDK7 (By
 MOD_RES 577 577 Phosphoserine (By similarity).
 MOD_RES 582 582 Phosphotyrosine (By similarity).
 MOD_RES 583 583 Phosphothreonine (By similarity).
 MOD_RES 739 739 Phosphothreonine (By similarity).
 MOD_RES 740 740 Phosphoserine (By similarity).  
Keyword
 Alternative initiation; Alternative splicing; Apoptosis; ATP-binding; Cell cycle; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 783 AA 
Protein Sequence
MGDEKDSWKV KTLDEILQEK KRRKEQEEKA EIKRLKNSDD RDSKRDSLEE GELRDHCMEI 60
TIRNSPYRRE DSMEDRGEED DSLAIKPPQQ MSRKEKVHHR KDEKRKEKWK HARVKEREHE 120
RRKRHREEQD KARREWERQK RREMAREHSR RERDRLEQLE RKRERERKMR EQQKEQREQK 180
ERERRAEERR KEREARREVS AHHRTMREDY SDKVKASHWS RSPPRPPRER FELGDGRKPG 240
EARPAPAQKP AQLKEEKMEE RDLLSDLQDI SDSERKTSSA ESSSAESGSG SEEEEEEEEE 300
EEEEGSTSEE SEEEEEEEEE EEEETGSNSE EASEQSAEEV SEEEMSEDEE RENENHLLVV 360
PESRFDRDSG ESEEAEEEVG EGTPQSSALT EGDYVPDSPA LLPIELKQEL PKYLPALQGC 420
RSVEEFQCLN RIEEGTYGVV YRAKDKKTDE IVALKRLKME KEKEGFPITS LREINTILKA 480
QHPNIVTVRE IVVGSNMDKI YIVMNYVEHD LKSLMETMKQ PFLPGEVKTL MIQLLRGVKH 540
LHDNWILHRD LKTSNLLLSH AGILKVGDFG LAREYGSPLK AYTPVVVTQW YRAPELLLGA 600
KEYSTAVDMW SVGCIFGELL TQKPLFPGNS EIDQINKVFK ELGTPSEKIW PGYSELPVVK 660
KMTFSEHPYN NLRKRFGALL SDQGFDLMNK FLTYFPGRRI SAEDGLKHEY FRETPLPIDP 720
SMFPTWPAKS EQQRVKRGTS PRPPEGGLGY SQLGDDDLKE TGFHLTTTNQ GASAAGPGFS 780
LKF 783 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IDA:UniProtKB.
 GO:0004693; F:cyclin-dependent protein serine/threonine kinase activity; IEA:EC.
 GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.
 GO:0006915; P:apoptotic process; NAS:UniProtKB.
 GO:0007067; P:mitosis; NAS:UniProtKB.
 GO:0001558; P:regulation of cell growth; IEP:UniProtKB.
 GO:0050684; P:regulation of mRNA processing; IDA:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; NAS:UniProtKB. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS