CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021541
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Leucine-rich repeat-containing protein 40 
Protein Synonyms/Alias
  
Gene Name
 LRRC40 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
37GLLKAARKSGQLNLSubiquitination[1, 2]
86WEQTDLTKLIISNNKubiquitination[3, 4]
93KLIISNNKLQSLTDDubiquitination[2, 3, 4, 5, 6]
141NVSHNKLKILPEEITubiquitination[2]
210NLSSNELKSLPAEINubiquitination[2]
302DLRDNKLKSVPDEIIubiquitination[2]
356IRREIISKGTQEVLKubiquitination[2]
363KGTQEVLKYLRSKIKubiquitination[2]
368VLKYLRSKIKDDGPSubiquitination[2]
370KYLRSKIKDDGPSQSubiquitination[2]
434VTSINFSKNQLCEIPubiquitination[2]
Reference
 [1] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
 REPEAT 83 104 LRR 1.
 REPEAT 106 127 LRR 2.
 REPEAT 129 150 LRR 3.
 REPEAT 152 173 LRR 4.
 REPEAT 175 196 LRR 5.
 REPEAT 198 219 LRR 6.
 REPEAT 221 242 LRR 7.
 REPEAT 244 265 LRR 8.
 REPEAT 266 286 LRR 9.
 REPEAT 290 311 LRR 10.
 REPEAT 313 335 LRR 11.
 REPEAT 336 356 LRR 12.
 REPEAT 400 421 LRR 13.
 REPEAT 426 447 LRR 14.
 REPEAT 450 472 LRR 15.
 REPEAT 473 494 LRR 16.
 REPEAT 496 517 LRR 17.
 REPEAT 519 540 LRR 18.
 REPEAT 543 564 LRR 19.
 REPEAT 566 586 LRR 20.
 MOD_RES 71 71 Phosphoserine.  
Keyword
 Complete proteome; Leucine-rich repeat; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 602 AA 
Protein Sequence
MSRLKRIAGQ DLRAGFKAGG RDCGTSVPQG LLKAARKSGQ LNLSGRNLSE VPQCVWRINV 60
DIPEEANQNL SFGATERWWE QTDLTKLIIS NNKLQSLTDD LRLLPALTVL DIHDNQLTSL 120
PSAIRELENL QKLNVSHNKL KILPEEITNL RNLKCLYLQH NELTCISEGF EQLSNLEDLD 180
LSNNHLTTVP ASFSSLSSLV RLNLSSNELK SLPAEINRMK RLKHLDCNSN LLETIPPELA 240
GMESLELLYL RRNKLRFLPE FPSCSLLKEL HVGENQIEML EAEHLKHLNS ILVLDLRDNK 300
LKSVPDEIIL LRSLERLDLS NNDISSLPYS LGNLHLKFLA LEGNPLRTIR REIISKGTQE 360
VLKYLRSKIK DDGPSQSESA TETAMTLPSE SRVNIHAIIT LKILDYSDKQ ATLIPDEVFD 420
AVKSNIVTSI NFSKNQLCEI PKRMVELKEM VSDVDLSFNK LSFISLELCV LQKLTFLDLR 480
NNFLNSLPEE MESLVRLQTI NLSFNRFKML PEVLYRIFTL ETILISNNQV GSVDPQKMKM 540
MENLTTLDLQ NNDLLQIPPE LGNCVNLRTL LLDGNPFRVP RAAILMKGTA AILEYLRDRI 600
PT 602 
Gene Ontology
  
Interpro
 IPR001611; Leu-rich_rpt.
 IPR025875; Leu-rich_rpt_4.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR015766; Leu_rich_rpt-containing_40. 
Pfam
 PF00560; LRR_1
 PF12799; LRR_4 
SMART
 SM00369; LRR_TYP 
PROSITE
 PS51450; LRR 
PRINTS