CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019825
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Plakophilin-2 
Protein Synonyms/Alias
  
Gene Name
 PKP2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
37LALPSEAKLKLAGSSubiquitination[1]
112PKTYDMLKAGTTATYubiquitination[1]
470WNLSSNDKLKNLMITubiquitination[2]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 May play a role in junctional plaques. 
Sequence Annotation
 REPEAT 341 383 ARM 1.
 REPEAT 385 424 ARM 2.
 REPEAT 427 467 ARM 3.
 REPEAT 571 616 ARM 4.
 REPEAT 671 711 ARM 5.
 REPEAT 719 758 ARM 6.
 REPEAT 763 804 ARM 7.
 REPEAT 807 849 ARM 8.
 MOD_RES 44 44 Phosphoserine.
 MOD_RES 132 132 Phosphoserine.
 MOD_RES 151 151 Phosphoserine.
 MOD_RES 154 154 Phosphoserine.
 MOD_RES 155 155 Phosphoserine.
 MOD_RES 169 169 Phosphoserine.
 MOD_RES 197 197 Phosphoserine.
 MOD_RES 251 251 Phosphoserine.
 MOD_RES 329 329 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Cardiomyopathy; Cell adhesion; Cell junction; Complete proteome; Disease mutation; Nucleus; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 881 AA 
Protein Sequence
MAAPGAPAEY GYIRTVLGQQ ILGQLDSSSL ALPSEAKLKL AGSSGRGGQT VKSLRIQEQV 60
QQTLARKGRS SVGNGNLHRT SSVPEYVYNL HLVENDFVGG RSPVPKTYDM LKAGTTATYE 120
GRWGRGTAQY SSQKSVEERS LRHPLRRLEI SPDSSPERAH YTHSDYQYSQ RSQAGHTLHH 180
QESRRAALLV PPRYARSEIV GVSRAGTTSR QRHFDTYHRQ YQHGSVSDTV FDSIPANPAL 240
LTYPRPGTSR SMGNLLEKEN YLTAGLTVGQ VRPLVPLQPV TQNRASRSSW HQSSFHSTRT 300
LREAGPSVAV DSSGRRAHLT VGQAAAGGSG NLLTERSTFT DSQLGNADME MTLERAVSML 360
EADHMLPSRI SAAATFIQHE CFQKSEARKR VNQLRGILKL LQLLKVQNED VQRAVCGALR 420
NLVFEDNDNK LEVAELNGVP RLLQVLKQTR DLETKKQITG LLWNLSSNDK LKNLMITEAL 480
LTLTENIIIP FSGWPEGDYP KANGLLDFDI FYNVTGCLRN MSSAGADGRK AMRRCDGLID 540
SLVHYVRGTI ADYQPDDKAT ENCVCILHNL SYQLEAELPE KYSQNIYIQN RNIQTDNNKS 600
IGCFGSRSRK VKEQYQDVPM PEEKSNPKGV EWLWHSIVIR MYLSLIAKSV RNYTQEASLG 660
ALQNLTAGSG PMPTSVAQTV VQKESGLQHT RKMLHVGDPS VKKTAISLLR NLSRNLSLQN 720
EIAKETLPDL VSIIPDTVPS TDLLIETTAS ACYTLNNIIQ NSYQNARDLL NTGGIQKIMA 780
ISAGDAYASN KASKAASVLL YSLWAHTELH HAYKKAQFKK TDFVNSRTAK AYHSLKD 837 
Gene Ontology
 GO:0005912; C:adherens junction; ISS:BHF-UCL.
 GO:0030057; C:desmosome; NAS:UniProtKB.
 GO:0016021; C:integral to membrane; TAS:ProtInc.
 GO:0014704; C:intercalated disc; ISS:BHF-UCL.
 GO:0005882; C:intermediate filament; ISS:BHF-UCL.
 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0005886; C:plasma membrane; TAS:ProtInc.
 GO:0019215; F:intermediate filament binding; IDA:BHF-UCL.
 GO:0044325; F:ion channel binding; ISS:BHF-UCL.
 GO:0032947; F:protein complex scaffold; IMP:BHF-UCL.
 GO:0017080; F:sodium channel regulator activity; ISS:BHF-UCL.
 GO:0034334; P:adherens junction maintenance; ISS:BHF-UCL.
 GO:0086069; P:bundle of His cell to Purkinje myocyte communication; IMP:BHF-UCL.
 GO:0086064; P:cell communication by electrical coupling involved in cardiac conduction; ISS:BHF-UCL.
 GO:0016337; P:cell-cell adhesion; NAS:UniProtKB.
 GO:0086019; P:cell-cell signaling involved in cardiac conduction; IMP:BHF-UCL.
 GO:0002159; P:desmosome assembly; IMP:BHF-UCL.
 GO:0016264; P:gap junction assembly; ISS:BHF-UCL.
 GO:0045110; P:intermediate filament bundle assembly; IMP:BHF-UCL.
 GO:0055088; P:lipid homeostasis; ISS:BHF-UCL.
 GO:0048496; P:maintenance of organ identity; IMP:BHF-UCL.
 GO:0030336; P:negative regulation of cell migration; ISS:BHF-UCL.
 GO:0008285; P:negative regulation of cell proliferation; ISS:BHF-UCL.
 GO:0010765; P:positive regulation of sodium ion transport; ISS:BHF-UCL.
 GO:0086091; P:regulation of heart rate by cardiac conduction; IMP:BHF-UCL.
 GO:2000810; P:regulation of tight junction assembly; ISS:BHF-UCL.
 GO:0086005; P:regulation of ventricular cardiac muscle cell action potential; IMP:BHF-UCL.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IMP:BHF-UCL. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR000225; Armadillo. 
Pfam
 PF00514; Arm 
SMART
 SM00185; ARM 
PROSITE
 PS50176; ARM_REPEAT 
PRINTS