UniProt Accession

 KCRB_MOUSE; Q04447; Q3KQP4; Q3TKI3; Q3U5P5; Q3UF71; Q9CXK6 

Genbank Protein ID

 M74149; L09069; AK002467; AK014299; AK148885; AK152388; AK153484; AK166980; AK161990; AK167034; BC015271; BC106109; X04591 

Genbank Nucleotide ID

 AAA37462.1; AAA37455.1; BAB22121.1; BAB29254.1; BAE28690.1; BAE31176.1; BAE32032.1; BAE39162.1; BAE36669.1; BAE39205.1; AAH15271.1; AAI06110.2; CAA28259.1 

Protein Name

 Creatine kinase B-type 

Protein Synonyms/Alias

 B-CK; Creatine kinase B chain 

Gene Name

 Ckb 

Gene Synonyms/Alias

 Ckbb 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
107	YQPSDEHKTDLNPDN	ubiquitination	[1]
156	GERRAIEKLAVEALS	ubiquitination	[1]
196	DDHFLFDKPVSPLLL	ubiquitination	[1]
242	LRVISMQKGGNMKEV	ubiquitination	[1]
265	TQIETLFKSKNYEFM	ubiquitination	[1]
298	LRAGVHIKLPHLGKH	ubiquitination	[1]
304	IKLPHLGKHEKFSEV	ubiquitination	[1]
307	PHLGKHEKFSEVLKR	ubiquitination	[1]
313	EKFSEVLKRLRLQKR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. 

Sequence Annotation

 DOMAIN 11 98 Phosphagen kinase N-terminal.
 DOMAIN 125 367 Phosphagen kinase C-terminal.
 NP_BIND 128 132 ATP (By similarity).
 NP_BIND 320 325 ATP (By similarity).
 BINDING 130 130 ATP (By similarity).
 BINDING 132 132 ATP (By similarity).
 BINDING 191 191 ATP (By similarity).
 BINDING 232 232 Substrate (By similarity).
 BINDING 236 236 ATP (By similarity).
 BINDING 285 285 Substrate (By similarity).
 BINDING 292 292 ATP (By similarity).
 BINDING 320 320 ATP (By similarity).
 BINDING 335 335 ATP (By similarity).
 MOD_RES 4 4 Phosphoserine (By similarity).
 MOD_RES 35 35 Phosphothreonine (By similarity).
 MOD_RES 39 39 Phosphotyrosine.
 MOD_RES 125 125 Phosphotyrosine.
 MOD_RES 164 164 Phosphoserine.
 MOD_RES 199 199 Phosphoserine (By similarity).
 MOD_RES 269 269 Nitrated tyrosine.  

Keyword

 ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Kinase; Nitration; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 381 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004111; F:creatine kinase activity; IEA:EC.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0030644; P:cellular chloride ion homeostasis; IEA:Compara. 

Interpro

 IPR000749; ATP-guanido_PTrfase.
 IPR022415; ATP-guanido_PTrfase_AS.
 IPR022414; ATP-guanido_PTrfase_cat.
 IPR022413; ATP-guanido_PTrfase_N.
 IPR014746; Gln_synth/guanido_kin_cat_dom. 

Pfam

 PF00217; ATP-gua_Ptrans
 PF02807; ATP-gua_PtransN 

SMART

  

PROSITE

 PS00112; PHOSPHAGEN_KINASE
 PS51510; PHOSPHAGEN_KINASE_C
 PS51509; PHOSPHAGEN_KINASE_N 

PRINTS