UniProt Accession

 ACOT8_MOUSE; P58137; Q8VHM4 

Genbank Protein ID

 AF441166; BC005792 

Genbank Nucleotide ID

 AAL35333.1; AAH05792.1 

Protein Name

 Acyl-coenzyme A thioesterase 8 

Protein Synonyms/Alias

 Acyl-CoA thioesterase 8; Choloyl-coenzyme A thioesterase; Peroxisomal acyl-CoA thioesterase 2; PTE-2; Peroxisomal acyl-coenzyme A thioester hydrolase 1; PTE-1; Peroxisomal long-chain acyl-CoA thioesterase 1 

Gene Name

 Acot8 

Gene Synonyms/Alias

 Pte1; Pte2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
92	FVRAGDPKVPVLYHV	acetylation	[1]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium- length fatty acyl-CoAs. May be involved in the metabolic regulation of peroxisome proliferation. 

Sequence Annotation

 MOTIF 318 320 Microbody targeting signal (Potential).
 ACT_SITE 233 233 Charge relay system (By similarity).
 ACT_SITE 255 255 Charge relay system (By similarity).
 ACT_SITE 305 305 Charge relay system (By similarity).
 MOD_RES 2 2 Phosphoserine.  

Keyword

 Complete proteome; Hydrolase; Peroxisome; Peroxisome biogenesis; Phosphoprotein; Reference proteome; Serine esterase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 320 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005782; C:peroxisomal matrix; IEA:Compara.
 GO:0005777; C:peroxisome; IDA:HGNC.
 GO:0047617; F:acyl-CoA hydrolase activity; IDA:MGI.
 GO:0004091; F:carboxylesterase activity; IEA:UniProtKB-KW.
 GO:0033882; F:choloyl-CoA hydrolase activity; IEA:EC.
 GO:0052815; F:medium-chain acyl-CoA hydrolase activity; IEA:Compara.
 GO:0016290; F:palmitoyl-CoA hydrolase activity; IEA:Compara.
 GO:0006637; P:acyl-CoA metabolic process; IDA:MGI.
 GO:0043649; P:dicarboxylic acid catabolic process; IEA:Compara.
 GO:0016559; P:peroxisome fission; IEA:Compara. 

Interpro

 IPR003703; Acyl_CoA_thio. 

Pfam

  

SMART

  

PROSITE

  

PRINTS