| Tag | Content |
|---|
| CPLM ID | CPLM-015017 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein lin-54 homolog |
Protein Synonyms/Alias | CXC domain-containing protein 1 |
Gene Name | LIN54 |
Gene Synonyms/Alias | CXCDC1; KIAA2037 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 11 | VPAEIAKKPRTPTSG | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner. |
Sequence Annotation | DOMAIN 521 634 CRC.
MOD_RES 244 244 N6-acetyllysine.
MOD_RES 249 249 N6-acetyllysine.
MOD_RES 310 310 Phosphoserine.
MOD_RES 314 314 Phosphoserine. |
Keyword | Acetylation; Activator; Alternative splicing; Cell cycle; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 749 AA |
Protein Sequence | MEVVPAEIAK KPRTPTSGPV ITKLIFAKPI NSKAVTGQTT QVSPPVIAGR VLSQSTPGTP 60
SKTITISESG VIGSTLNSTT QTPNKIAISP LKSPNKAVKS TVQTITVGGV STSQFKTIIP 120
LATAPNVQQI QVPGSKFHYV RLVTATSASS STQPVSQNPS TNTQPLQQAK PVVVNTTPVR 180
MSVPIVSAQA VKQVVPKPIN PTSQIVTTSQ PQQRLIMPAT PLPQIQPNLT NLPPGTVLAP 240
APGTGNVGYA VLPAQYVTQL QQSSYVSIAS NSTFTGTSGI QTQARLPFNG IIPSESASRP 300
RKPCNCTKSL CLKLYCDCFA NGEFCNNCNC TNCYNNLEHE NERQKAIKAC LDRNPEAFKP 360
KIGKGKEGES DRRHSKGCNC KRSGCLKNYC ECYEAKIMCS SICKCIGCKN FEESPERKTL 420
MHLADAAEVR VQQQTAAKTK LSSQISDLLT RPTPALNSGG GKLPFTFVTK EVAEATCNCL 480
LAQAEQADKK GKSKAAAERM ILEEFGRCLM SVINSAGKAK SDPCAMNC 528 |
Gene Ontology | GO:0005654; C:nucleoplasm; TAS:Reactome. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0000278; P:mitotic cell cycle; TAS:Reactome. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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