| Tag | Content |
|---|
| CPLM ID | CPLM-022504 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | CpG-binding protein |
Protein Synonyms/Alias | CXXC-type zinc finger protein 1; PHD finger and CXXC domain-containing protein 1 |
Gene Name | CXXC1 |
Gene Synonyms/Alias | CFP1; CGBP; PCCX1; PHF18 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 371 | HPERADAKDPASLPQ | ubiquitination | [1] | | 402 | CSDDCGMKLAANRIY | ubiquitination | [1] | | 431 | CIAEEHGKKLLERIR | ubiquitination | [1] | | 432 | IAEEHGKKLLERIRR | ubiquitination | [1] | | 466 | EAIILRAKQQAVRED | ubiquitination | [1] | | 512 | HMERCYAKYESQTSF | ubiquitination | [1] | | 543 | DVYNPQSKTYCKRLQ | ubiquitination | [1] | | 561 | PEHSRDPKVPADEVC | ubiquitination | [1] | | 599 | NRHYCWEKLRRAEVD | ubiquitination | [1] | | 615 | ERVRVWYKLDELFEQ | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG. |
Sequence Annotation | ZN_FING 28 76 PHD-type.
ZN_FING 160 209 CXXC-type.
MOD_RES 1 1 N-acetylmethionine.
MOD_RES 6 6 Phosphoserine.
MOD_RES 19 19 Phosphoserine.
MOD_RES 227 227 Phosphothreonine. |
Keyword | 3D-structure; Acetylation; Activator; Alternative splicing; Coiled coil; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Zinc; Zinc-finger. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 656 AA |
Protein Sequence | MEGDGSDPEP PDAGEDSKSE NGENAPIYCI CRKPDINCFM IGCDNCNEWF HGDCIRITEK 60
MAKAIREWYC RECREKDPKL EIRYRHKKSR ERDGNERDSS EPRDEGGGRK RPVPDPDLQR 120
RAGSGTGVGA MLARGSASPH KSSPQPLVAT PSQHHQQQQQ QIKRSARMCG ECEACRRTED 180
CGHCDFCRDM KKFGGPNKIR QKCRLRQCQL RARESYKYFP SSLSPVTPSE SLPRPRRPLP 240
TQQQPQPSQK LGRIREDEGA VASSTVKEPP EATATPEPLS DEDLPLDPDL YQDFCAGAFD 300
DHGLPWMSDT EESPFLDPAL RKRAVKVKHV KRREKKSEKK VMERKEERYK RHRQKQKHKD 360
KWKHPERADA KDPASLPQCL GPGCVRPAQP SSKYCSDDCG MKLAANRIYE ILPQRIQQWQ 420
QSPCIAEEHG KKLLERIRRE QQSARTRLQE MERRFHELEA IILRAKQQAV REDEESNEGD 480
SDDTDLQIFC VSCGHPINPR VALRHMERCY AKYESQTSFG SMYPTRIEGA TRLFCDVYNP 540
QSKTYCKRLQ VLCPEHSRDP KVPADEVCGC PLVRDVFELT GDFCRLPKRQ CNRHYCWEKL 600
RRAEVDLERV RVWYKLDELF EQERNVRTAM TNRAGLLALM LHQTIQHDPL TTDLRSSADR 660 |
Gene Ontology | GO:0016363; C:nuclear matrix; IEA:Compara. GO:0016607; C:nuclear speck; IDA:LIFEdb. GO:0048188; C:Set1C/COMPASS complex; IDA:UniProtKB. GO:0045322; F:unmethylated CpG binding; IDA:UniProtKB. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0006987; P:activation of signaling protein activity involved in unfolded protein response; TAS:Reactome. GO:0051568; P:histone H3-K4 methylation; IDA:UniProtKB. GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |