UniProt Accession

 GLF_ECOLI; P37747 

Genbank Protein ID

 U03041; U09876; U00096; AP009048 

Genbank Nucleotide ID

 AAC31632.1; AAB88403.1; AAC75097.1; BAA15878.1 

Protein Name

 UDP-galactopyranose mutase 

Protein Synonyms/Alias

 UGM; UDP-GALP mutase; Uridine 5-diphosphate galactopyranose mutase 

Gene Name

 glf 

Gene Synonyms/Alias

 yefE; b2036; JW2021 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
32	KKVLVIEKRNHIGGN	acetylation	[1]
87	NSPLAIYKDKLFNLP	acetylation	[1]
161	KQWGRSAKELPAFII	acetylation	[1]
169	ELPAFIIKRIPVRFT	acetylation	[1]
196	IPVGGYTKLIEKMLE	acetylation	[1]
200	GYTKLIEKMLEGVDV	acetylation	[1]
215	KLGIDFLKDKDSLAS	acetylation	[1]
250	ALEYRSLKFETERHE	acetylation	[1]
291	HFDYVETKHTVVTKE	acetylation	[1, 2]
297	TKHTVVTKEYPLEWK	acetylation	[1]
304	KEYPLEWKVGDEPYY	acetylation	[1]
317	YYPVNDNKNMELFKK	acetylation	[1]
323	NKNMELFKKYRELAS	acetylation	[1]
334	ELASREDKVIFGGRL	acetylation	[1]
345	GGRLAEYKYYDMHQV	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 

Functional Description

 Catalyzes the interconversion through a 2-keto intermediate of uridine diphosphogalactopyranose (UDP-GalP) into uridine diphosphogalactofuranose (UDP-GalF) (By similarity). 

Sequence Annotation

 NP_BIND 31 32 FAD.
 NP_BIND 56 57 FAD.
 NP_BIND 212 213 FAD.
 NP_BIND 347 352 FAD.
 BINDING 12 12 FAD; via amide nitrogen.
 BINDING 12 12 UDP-GalP; via amide nitrogen (By
 BINDING 39 39 FAD; via amide nitrogen.
 BINDING 80 80 UDP-GalP (By similarity).
 BINDING 152 152 UDP-GalP (By similarity).
 BINDING 156 156 UDP-GalP (By similarity).
 BINDING 181 181 UDP-GalP (By similarity).
 BINDING 268 268 UDP-GalP (By similarity).
 BINDING 278 278 UDP-GalP (By similarity).
 BINDING 311 311 UDP-GalP (By similarity).
 BINDING 340 340 FAD (By similarity).
 BINDING 346 346 UDP-GalP (By similarity).  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; FAD; Flavoprotein; Isomerase; Lipopolysaccharide biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 367 AA 

Protein Sequence

Gene Ontology

 GO:0008767; F:UDP-galactopyranose mutase activity; IDA:EcoCyc.
 GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR016040; NAD(P)-bd_dom.
 IPR004379; UDP-GALP_mutase.
 IPR015899; UDP-GalPyranose_mutase_C. 

Pfam

 PF03275; GLF 

SMART

  

PROSITE

  

PRINTS