UniProt Accession

 D6RIW1_HUMAN; D6RIW1 

Genbank Protein ID

 AC114947 

Genbank Nucleotide ID

  

Protein Name

 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 

Protein Synonyms/Alias

  

Gene Name

 HMGCS1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
46	YDGVDAGKYTIGLGQ	acetylation	[1, 2]
46	YDGVDAGKYTIGLGQ	ubiquitination	[3, 4, 5]

Reference

 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 96 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0008144; F:drug binding; IEA:Compara.
 GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:Compara.
 GO:0016853; F:isomerase activity; IEA:Compara.
 GO:0043177; F:organic acid binding; IEA:Compara.
 GO:0007420; P:brain development; IEA:Compara.
 GO:0071397; P:cellular response to cholesterol; IEA:Compara.
 GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IEA:Compara.
 GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
 GO:0001889; P:liver development; IEA:Compara.
 GO:0008584; P:male gonad development; IEA:Compara.
 GO:0001101; P:response to acid; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0055094; P:response to lipoprotein particle stimulus; IEA:Compara.
 GO:0009645; P:response to low light intensity stimulus; IEA:Compara.
 GO:0014074; P:response to purine-containing compound; IEA:Compara.
 GO:0046690; P:response to tellurium ion; IEA:Compara.
 GO:0033197; P:response to vitamin E; IEA:Compara. 

Interpro

 IPR013528; HMG_CoA_synth_N.
 IPR016039; Thiolase-like.
 IPR016038; Thiolase-like_subgr. 

Pfam

 PF01154; HMG_CoA_synt_N 

SMART

  

PROSITE

  

PRINTS