CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015625
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein FRA10AC1 
Protein Synonyms/Alias
  
Gene Name
 FRA10AC1 
Gene Synonyms/Alias
 C10orf4; PRO2972 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
36EDDLLLQKPFQKEKHacetylation[1, 2, 3]
36EDDLLLQKPFQKEKHubiquitination[4]
42QKPFQKEKHGKVAHKubiquitination[4]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 12 12 Phosphoserine (By similarity).
 MOD_RES 251 251 Phosphoserine.
 MOD_RES 252 252 Phosphoserine.
 MOD_RES 278 278 Phosphoserine.
 MOD_RES 283 283 Phosphoserine (By similarity).
 MOD_RES 285 285 Phosphoserine (By similarity).  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 315 AA 
Protein Sequence
MHGHGGYDSD FSDDERCGES SKRKKRTVED DLLLQKPFQK EKHGKVAHKQ VAAELLDREE 60
ARNRRFHLIA MDAYQRHTKF VNDYILYYGG KKEDFKRLGE NDKTDLDVIR ENHRFLWNEE 120
DEMDMTWEKR LAKKYYDKLF KEYCIADLSK YKENKFGFRW RVEKEVISGK GQFFCGNKYC 180
DKKEGLKSWE VNFGYIEHGE KRNALVKLRL CQECSIKLNF HHRRKEIKSK KRKDKTKKDC 240
EESSHKKSRL SSAEEASKKK DKGHSSSKKS EDSLLRNSDE EESASESELW KGPLPETDEK 300
SQEEEFDEYF QDLFL 315 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. 
Interpro
 IPR019129; Folate-sensitive_fs_Fra10Ac1. 
Pfam
 PF09725; Fra10Ac1 
SMART
  
PROSITE
  
PRINTS