UniProt Accession

 PHS_RAT; P61459; P70519; P80095; Q9D930 

Genbank Protein ID

 M83740; AJ005542; L04537 

Genbank Nucleotide ID

 CAA06587.1; AAA40609.1 

Protein Name

 Pterin-4-alpha-carbinolamine dehydratase 

Protein Synonyms/Alias

 PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; DCoH; Dimerization cofactor of HNF1; Phenylalanine hydroxylase-stimulating protein; Pterin carbinolamine dehydratase; PCD 

Gene Name

 Pcbd1 

Gene Synonyms/Alias

 Dcoh; Pcbd 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
36	EGRDAIFKQFHFKDF	acetylation	[1]
41	IFKQFHFKDFNRAFG	acetylation	[1]
59	RVALQAEKLDHHPEW	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. Coactivator for HNF1A-dependent transcription. Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity. 

Sequence Annotation

 REGION 61 63 Substrate binding.
 REGION 78 81 Substrate binding.
 MOD_RES 2 2 N-acetylalanine.  

Keyword

 3D-structure; Acetylation; Activator; Complete proteome; Cytoplasm; Direct protein sequencing; Lyase; Nucleus; Reference proteome; Tetrahydrobiopterin biosynthesis; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 104 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IPI:MGI.
 GO:0008124; F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity; TAS:ProtInc.
 GO:0004505; F:phenylalanine 4-monooxygenase activity; IEA:Compara.
 GO:0003713; F:transcription coactivator activity; IDA:MGI.
 GO:0006558; P:L-phenylalanine metabolic process; TAS:ProtInc.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:MGI.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0051289; P:protein homotetramerization; IEA:Compara.
 GO:0043496; P:regulation of protein homodimerization activity; IDA:MGI.
 GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR001533; Trans/pterin_deHydtase. 

Pfam

 PF01329; Pterin_4a 

SMART

  

PROSITE

  

PRINTS