CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013588
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DnaJ homolog subfamily C member 21 
Protein Synonyms/Alias
 DnaJ homolog subfamily A member 5; Protein GS3 
Gene Name
 DNAJC21 
Gene Synonyms/Alias
 DNAJA5 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
2******MKCHYEALGmethylation[1]
231VEEQNAEKARKAEEMubiquitination[2]
Reference
 [1] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May act as a co-chaperone for HSP70. 
Sequence Annotation
 DOMAIN 3 69 J.
 ZN_FING 314 338 C2H2-type 1.
 ZN_FING 482 506 C2H2-type 2.
 MOD_RES 283 283 Phosphoserine.
 MOD_RES 302 302 Phosphoserine.
 MOD_RES 370 370 Phosphoserine.  
Keyword
 Alternative splicing; Chaperone; Complete proteome; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 531 AA 
Protein Sequence
MKCHYEALGV RRDASEEELK KAYRKLALKW HPDKNLDNAA EAAEQFKLIQ AAYDVLSDPQ 60
ERAWYDNHRE ALLKGGFDGE YQDDSLDLLR YFTVTCYSGY GDDEKGFYTV YRNVFEMIAK 120
EELESVLEEE VDDFPTFGDS QSDYDTVVHP FYAYWQSFCT QKNFAWKEEY DTRQASNRWE 180
KRAMEKENKK IRDKARKEKN ELVRQLVAFI RKRDKRVQAH RKLVEEQNAE KARKAEEMRR 240
QQKLKQAKLV EQYREQSWMT MANLEKELQE MEARYEKEFG DGSDENEMEE HELKDEEDGK 300
DSDEAEDAEL YDDLYCPACD KSFKTEKAMK NHEKSKKHRE MVALLKQQLE EEEENFSRPQ 360
IDENPLDDNS EEEMEDAPKQ KLSKKQKKKK QKPAQNYDDN FNVNGPGEGV KVDPEDTNLN 420
QDSAKELEDS PQENVSVTEI IKPCDDPKSE AKSVPKPKGK KTKDMKKPVR VPAEPQTMSV 480
LISCTTCHSE FPSRNKLFDH LKATGHARAP SSSSLNSATS SQSKKEKRKN R 531 
Gene Ontology
 GO:0005840; C:ribosome; NAS:UniProtKB.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006457; P:protein folding; NAS:UniProtKB. 
Interpro
 IPR001623; DnaJ_domain.
 IPR018253; DnaJ_domain_CS.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR022755; Znf_C2H2_jaz.
 IPR003604; Znf_U1. 
Pfam
 PF00226; DnaJ
 PF12171; zf-C2H2_jaz 
SMART
 SM00271; DnaJ
 SM00355; ZnF_C2H2
 SM00451; ZnF_U1 
PROSITE
 PS00636; DNAJ_1
 PS50076; DNAJ_2
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS
 PR00625; JDOMAIN.