CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013764
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Caprin-1 
Protein Synonyms/Alias
 Cytoplasmic activation- and proliferation-associated protein 1; GPI-anchored protein p137; GPI-p137; p137GPI; RNA granule protein 105 
Gene Name
 Caprin1 
Gene Synonyms/Alias
 Gpiap1; Rng105 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
61QILGVIDKKLRNLEKacetylation[1]
72NLEKKKGKLDDYQERacetylation[1]
108TNNLEFAKELQRSFMubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 May regulate the transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. 
Sequence Annotation
 REGION 358 379 G3BP1-binding (By similarity).
 MOD_RES 2 2 N-acetylproline (By similarity).
 MOD_RES 10 10 Phosphoserine (By similarity).  
Keyword
 Acetylation; Cell projection; Coiled coil; Complete proteome; Cytoplasm; Differentiation; Glycoprotein; Phosphoprotein; Protein synthesis inhibitor; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 707 AA 
Protein Sequence
MPSATSHSGS GSKSSGPPPP SGSSGSEAAA GAAAPASQHP ATGTGAVQTE AMKQILGVID 60
KKLRNLEKKK GKLDDYQERM NKGERLNQDQ LDAVSKYQEV TNNLEFAKEL QRSFMALSQD 120
IQKTIKKTAR REQLMREEAE QKRLKTVLEL QYVLDKLGDD DVRTDLKQGL SGVPILSEEE 180
LSLLDEFYKL VDPERDMSLR LNEQYEHASI HLWDLLEGKE KPVCGTTYKA LKEIVERVFQ 240
SNYFDSTHNH QNGLCEEEEA ASAPIVEDQV AEAEPEPTEE YTEQSEVEST EYVNRQFMAE 300
TQFSSGEKEQ VDEWAVETVE VVNSLQQQPQ AASPSVPEPH SLTPVAQSDP LVRRQRVQDL 360
MAQMQGPYNF IQDSMLDFEN QTLDPAIVSA QPMNPTQNMD MPQLVCPQVH SESRLAQSNQ 420
VPVQPEATQV PLVSSTSEGY TASQPLYQPS HAAEQRPQKE PIDQIQATIS LNTEQTTASS 480
SLPAASQPQV FQAGASKPLH SSGINVNAAP FQSMQTVFNM NAPVPPVNEP ETLKQQSQYQ 540
ASYNQSFSSQ PHQVEQTELQ QDQLQTVVGT YHGSQDQPHQ VPGNHQQPPQ QSTGFPRSSQ 600
PYYNSRGVSR GGSRGARGLM NGYRGPANGF RGGYDGYRSS FSNTPNSGYT QSQFNAPRDY 660
SGYQRDGYQQ NFKRGSGQSG PRGAPRGRGG PPRPNRGMPQ MNTQQVN 707 
Gene Ontology
 GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
 GO:0010494; C:cytoplasmic stress granule; IDA:UniProtKB.
 GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
 GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
 GO:0003723; F:RNA binding; IDA:UniProtKB.
 GO:0017148; P:negative regulation of translation; IDA:UniProtKB.
 GO:0050775; P:positive regulation of dendrite morphogenesis; ISS:UniProtKB.
 GO:0061003; P:positive regulation of dendritic spine morphogenesis; ISS:UniProtKB. 
Interpro
 IPR022070; Caprin-1_C. 
Pfam
 PF12287; Caprin-1_C 
SMART
  
PROSITE
  
PRINTS