UniProt Accession

 HPT_HUMAN; P00738; B0AZL5; P00737; Q0VAC4; Q2PP15; Q3B7J0; Q6LBY9; Q9UC67 

Genbank Protein ID

 K00422; K01763; L29394; X00637; X01793; X01786; X02206; X01789; X01791; M10935; M69197; AK314700; DQ314870; BC107587; BC121125; M13192; AC004682; X00606 

Genbank Nucleotide ID

 AAA52687.1; AAA52684.1; AAA52685.1; CAA25267.1; CAA25926.1; CAA25926.1; CAA25926.1; CAA25926.1; CAA25926.1; AAA88080.1; AAA88078.1; BAF98793.1; ABC40729.1; AAI07588.1; AAI21126.1; AAC27432.1; CAA25248.1 

Protein Name

 Haptoglobin 

Protein Synonyms/Alias

 Zonulin; Haptoglobin alpha chain; Haptoglobin beta chain 

Gene Name

 HP 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
53	HSVRYQCKNYYKLRT	glycation	[1]
321	EGSTVPEKKTPKSPV	glycation	[1]

Reference

 [1] Proteomic profiling of nonenzymatically glycated proteins in human plasma and erythrocyte membranes.
 Zhang Q, Tang N, Schepmoes AA, Phillips LS, Smith RD, Metz TO.
 J Proteome Res. 2008 May;7(5):2025-32. [PMID: 18396901] 

Functional Description

 As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. 

Sequence Annotation

 DOMAIN 31 88 Sushi 1.
 DOMAIN 90 147 Sushi 2.
 DOMAIN 162 404 Peptidase S1.
 REGION 318 323 Interaction with CD163 (By similarity).
 CARBOHYD 184 184 N-linked (GlcNAc...).
 CARBOHYD 207 207 N-linked (GlcNAc...).
 CARBOHYD 211 211 N-linked (GlcNAc...).
 CARBOHYD 241 241 N-linked (GlcNAc...) (complex).
 DISULFID 33 33 Interchain.
 DISULFID 52 86
 DISULFID 92 92 Interchain.
 DISULFID 111 145
 DISULFID 149 266 Interchain (between alpha and beta
 DISULFID 309 340
 DISULFID 351 381  

Keyword

 Acute phase; Antibiotic; Antimicrobial; Antioxidant; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Hemoglobin-binding; Immunity; Polymorphism; Reference proteome; Repeat; Secreted; Serine protease homolog; Signal; Sushi. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 406 AA 

Protein Sequence

Gene Ontology

 GO:0071682; C:endocytic vesicle lumen; TAS:Reactome.
 GO:0005615; C:extracellular space; IDA:MGI.
 GO:0031838; C:haptoglobin-hemoglobin complex; IDA:BHF-UCL.
 GO:0016209; F:antioxidant activity; IEA:UniProtKB-KW.
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0030492; F:hemoglobin binding; IDA:BHF-UCL.
 GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
 GO:0006879; P:cellular iron ion homeostasis; NAS:UniProtKB.
 GO:0006952; P:defense response; TAS:ProtInc.
 GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
 GO:0008152; P:metabolic process; IEA:GOC.
 GO:2000296; P:negative regulation of hydrogen peroxide catabolic process; IDA:BHF-UCL.
 GO:0051354; P:negative regulation of oxidoreductase activity; IDA:BHF-UCL.
 GO:0010942; P:positive regulation of cell death; IDA:BHF-UCL.
 GO:0042542; P:response to hydrogen peroxide; IDA:BHF-UCL. 

Interpro

 IPR001254; Peptidase_S1.
 IPR001314; Peptidase_S1A.
 IPR000436; Sushi_SCR_CCP.
 IPR009003; Trypsin-like_Pept_dom. 

Pfam

 PF00089; Trypsin 

SMART

 SM00032; CCP
 SM00020; Tryp_SPc 

PROSITE

 PS50923; SUSHI
 PS50240; TRYPSIN_DOM 

PRINTS

 PR00722; CHYMOTRYPSIN.