CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039919
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Aldehyde dehydrogenase family 16 member A1 
Protein Synonyms/Alias
  
Gene Name
 ALDH16A1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
82ASQPGIRKVAFCGAPubiquitination[1, 2]
250ASPFRTAKEALLVANubiquitination[1, 2, 3, 4, 5, 6]
305SVPTGGCKESGCSWHubiquitination[2]
336ARLSCLSKNLNYDTFubiquitination[5]
401YVAEGGAKDIRGAVEubiquitination[2, 3, 4, 5, 6]
455ERQGAELKAAEAEVEubiquitination[2, 4, 6]
631GLRVARTKALWLPMGubiquitination[1, 2]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 639 AA 
Protein Sequence
MRTGVIGLIL PPTFSFLEMM WRICPALAVG CTVVALVPPA SPAPLLLAQL AGELGPFPGI 60
LNVLSGPASL VPILASQPGI RKVAFCGAPE EGRALRRSLA GECAELGLAL GTESLLLLTD 120
TADVDSAVEG VVDAAWSDRG PGGLRLLIQE SVWDEAMRRL QERMGRLRSG RGLDGAVDMG 180
ARGAAACDLV QRFVREAQSQ GAQVFQAGDV PSERPFYPPT LVSNLPPASP CAQVEVPWPV 240
VVASPFRTAK EALLVANGTP RGGSASVWSE RLGQALELGY GLQVGTVWIN AHGLRDPSVP 300
TGGCKESGCS WHGGPDGLYE YLRPSGTPAR LSCLSKNLNY DTFGLAVPST LPAGPEIGPS 360
PAPPYGLFVG GRFQAPGARS SRPIRDSSGN LHGYVAEGGA KDIRGAVEAA HQAFPGWAGQ 420
SPGARAALLW ALAAALERRK STLASRLERQ GAELKAAEAE VELSARRLRA WGARVQAQGH 480
TLQVAGLRGP VLRLREPLGV LAVVCPDEWP LLAFVSLLAP ALAYGNTVVM VPSAACPLLA 540
LEVCQDMATV FPAGLANVVT GDRDHLTRCL ALHQDVQAMW YFGSAQGSQF VEWASAGNLK 600
PVWASRGCPR AWDQEAEGAG PELGLRVART KALWLPMGD 639 
Gene Ontology
 GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro. 
Interpro
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom. 
Pfam
 PF00171; Aldedh 
SMART
  
PROSITE
  
PRINTS