CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008263
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Motor neuron and pancreas homeobox protein 1 
Protein Synonyms/Alias
 Homeobox protein HB9 
Gene Name
 MNX1 
Gene Synonyms/Alias
 HLXB9 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
225TAGMILPKMPDFNSQubiquitination[1]
240AQSNLLGKCRRPRTAubiquitination[1]
264EHQFKLNKYLSRPKRubiquitination[1]
322GGGGGAGKGGAEEPGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
 Putative transcription factor involved in pancreas development and function. 
Sequence Annotation
 DNA_BIND 241 300 Homeobox.  
Keyword
 Alternative splicing; Complete proteome; Disease mutation; DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 401 AA 
Protein Sequence
MEKSKNFRID ALLAVDPPRA ASAQSAPLAL VTSLAAAASG TGGGGGGGGA SGGTSGSCSP 60
ASSEPPAAPA DRLRAESPSP PRLLAAHCAL LPKPGFLGAG GGGGGTGGGH GGPHHHAHPG 120
AAAAAAAAAA AAAAGGLALG LHPGGAQGGA GLPAQAALYG HPVYGYSAAA AAAALAGQHP 180
ALSYSYPQVQ GAHPAHPADP IKLGAGTFQL DQWLRASTAG MILPKMPDFN SQAQSNLLGK 240
CRRPRTAFTS QQLLELEHQF KLNKYLSRPK RFEVATSLML TETQVKIWFQ NRRMKWKRSK 300
KAKEQAAQEA EKQKGGGGGA GKGGAEEPGA EELLGPPAPG DKGSGRRLRD LRDSDPEEDE 360
DEDDEDHFPY SNGASVHAAS SDCSSEDDSP PPRPSHQPAP Q 401 
Gene Ontology
 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; NAS:UniProtKB.
 GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc.
 GO:0060539; P:diaphragm development; IEA:Compara.
 GO:0021904; P:dorsal/ventral neural tube patterning; IEA:Compara.
 GO:0031018; P:endocrine pancreas development; IEA:Compara.
 GO:0006959; P:humoral immune response; TAS:ProtInc.
 GO:0008045; P:motor neuron axon guidance; IEA:Compara.
 GO:0021675; P:nerve development; IEA:Compara.
 GO:0001764; P:neuron migration; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0021520; P:spinal cord motor neuron cell fate specification; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR017970; Homeobox_CS.
 IPR020479; Homeobox_metazoa.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like. 
Pfam
 PF00046; Homeobox 
SMART
 SM00389; HOX 
PROSITE
 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2 
PRINTS
 PR00024; HOMEOBOX.