CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003443
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Arginine N-succinyltransferase 
Protein Synonyms/Alias
 AST; AOST 
Gene Name
 astA 
Gene Synonyms/Alias
 ydjV; b1747; JW1736 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
133FLDPDWRKEGNGYLLacetylation[1]
142GNGYLLSKSRFMFMAacetylation[1]
181PFWQSLGKRFFSMDFacetylation[1]
241PARAVLEKEGFRYRNacetylation[1]
325AAQLDALKCHAGDRVacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine. 
Sequence Annotation
 ACT_SITE 229 229 Proton donor (Potential).
 BINDING 125 125 Succinyl-CoA; via amide nitrogen  
Keyword
 Acyltransferase; Arginine metabolism; Complete proteome; Reference proteome; Stress response; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 344 AA 
Protein Sequence
MMVIRPVERS DVSALMQLAS KTGGGLTSLP ANEATLSARI ERAIKTWQGE LPKSEQGYVF 60
VLEDSETGTV AGICAIEVAV GLNDPWYNYR VGTLVHASKE LNVYNALPTL FLSNDHTGSS 120
ELCTLFLDPD WRKEGNGYLL SKSRFMFMAA FRDKFNDKVV AEMRGVIDEH GYSPFWQSLG 180
KRFFSMDFSR ADFLCGTGQK AFIAELMPKH PIYTHFLSQE AQDVIGQVHP QTAPARAVLE 240
KEGFRYRNYI DIFDGGPTLE CDIDRVRAIR KSRLVEVAEG QPAQGDFPAC LVANENYHHF 300
RVVLVRTDPA TERLILTAAQ LDALKCHAGD RVRLVRLCAE EKTA 344 
Gene Ontology
 GO:0008791; F:arginine N-succinyltransferase activity; IEA:HAMAP.
 GO:0019544; P:arginine catabolic process to glutamate; IEA:HAMAP.
 GO:0019545; P:arginine catabolic process to succinate; IEA:UniProtKB-UniPathway.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 
Interpro
 IPR016181; Acyl_CoA_acyltransferase.
 IPR007041; Arg_N-succinylTrfase_Ast/AOST.
 IPR017650; Arginine_N-succinylTrfase_AstA.
 IPR009010; Asp_de-COase-like_dom. 
Pfam
 PF04958; AstA 
SMART
  
PROSITE
  
PRINTS