CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005592
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Guanine nucleotide-binding protein subunit alpha-13 
Protein Synonyms/Alias
 G alpha-13; G-protein subunit alpha-13 
Gene Name
 Gna13 
Gene Synonyms/Alias
 Gna-13 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
175FQLGESVKYFLDNLDubiquitination[1]
214HEYDFEIKNVPFKMVubiquitination[1]
219EIKNVPFKMVDVGGQubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. 
Sequence Annotation
 NP_BIND 55 62 GTP (By similarity).
 NP_BIND 197 203 GTP (By similarity).
 NP_BIND 222 226 GTP (By similarity).
 NP_BIND 291 294 GTP (By similarity).
 METAL 62 62 Magnesium (By similarity).
 METAL 203 203 Magnesium (By similarity).
 BINDING 349 349 GTP; via amide nitrogen (By similarity).
 MOD_RES 203 203 Phosphothreonine (By similarity).
 LIPID 14 14 S-palmitoyl cysteine (By similarity).
 LIPID 18 18 S-palmitoyl cysteine (By similarity).  
Keyword
 3D-structure; Complete proteome; Direct protein sequencing; GTP-binding; Lipoprotein; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Palmitate; Phosphoprotein; Reference proteome; Transducer. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 377 AA 
Protein Sequence
MADFLPSRSV LSVCFPGCVL TNGEAEQQRK SKEIDKCLSR EKTYVKRLVK ILLLGAGESG 60
KSTFLKQMRI IHGQDFDQRA REEFRPTIYS NVIKGMRVLV DAREKLHIPW GDNKNQLHGD 120
KLMAFDTRAP MAAQGMVETR VFLQYLPAIR ALWEDSGIQN AYDRRREFQL GESVKYFLDN 180
LDKLGVPDYI PSQQDILLAR RPTKGIHEYD FEIKNVPFKM VDVGGQRSER KRWFECFDSV 240
TSILFLVSSS EFDQVLMEDR QTNRLTESLN IFETIVNNRV FSNVSIILFL NKTDLLEEKV 300
QVVSIKDYFL EFEGDPHCLR DVQKFLVECF RGKRRDQQQR PLYHHFTTAI NTENIRLVFR 360
DVKDTILHDN LKQLMLQ 377 
Gene Ontology
 GO:0031526; C:brush border membrane; IBA:RefGenome.
 GO:0005834; C:heterotrimeric G-protein complex; ISA:MGI.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0031752; F:D5 dopamine receptor binding; IBA:RefGenome.
 GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:RefGenome.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; ISA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004871; F:signal transducer activity; IBA:RefGenome.
 GO:0031702; F:type 1 angiotensin receptor binding; IBA:RefGenome.
 GO:0031584; P:activation of phospholipase D activity; IBA:RefGenome.
 GO:0007189; P:adenylate cyclase-activating G-protein coupled receptor signaling pathway; IGI:MGI.
 GO:0030154; P:cell differentiation; IDA:MGI.
 GO:0001701; P:in utero embryonic development; IGI:MGI.
 GO:0007243; P:intracellular protein kinase cascade; IDA:MGI.
 GO:0001569; P:patterning of blood vessels; IMP:MGI.
 GO:0030168; P:platelet activation; IMP:MGI.
 GO:0030334; P:regulation of cell migration; IMP:MGI.
 GO:0008360; P:regulation of cell shape; IDA:MGI.
 GO:0007266; P:Rho protein signal transduction; IDA:MGI. 
Interpro
 IPR000469; Gprotein_alpha_12.
 IPR001019; Gprotein_alpha_su.
 IPR011025; GproteinA_insert.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00503; G-alpha 
SMART
 SM00275; G_alpha 
PROSITE
  
PRINTS
 PR00318; GPROTEINA.
 PR00440; GPROTEINA12.