CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021778
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytoplasmic dynein 2 heavy chain 1 
Protein Synonyms/Alias
 Cytoplasmic dynein 2 heavy chain; Dynein cytoplasmic heavy chain 2; Dynein heavy chain isotype 1B; Dynein-like protein 4 
Gene Name
 Dync2h1 
Gene Synonyms/Alias
 Dhc1b; Dlp4; Dnch2; Dnchc2 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
1030ESHQLMIKDQIEVMKubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113
Functional Description
 May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis. May play a role in transport between endoplasmic reticulum and Golgi or organization of the Golgi in cells (By similarity). 
Sequence Annotation
 NP_BIND 145 152 ATP (Potential).
 NP_BIND 1689 1696 ATP (Potential).
 NP_BIND 1979 1986 ATP (Potential).
 NP_BIND 2291 2298 ATP (Potential).
 NP_BIND 2655 2662 ATP (Potential).
 REGION 1 1650 Stem (By similarity).
 REGION 1651 1875 AAA 1 (By similarity).
 REGION 1941 2161 AAA 2 (By similarity).
 REGION 2249 2505 AAA 3 (By similarity).
 REGION 2617 2862 AAA 4 (By similarity).
 REGION 2880 3168 Stalk (By similarity).
 REGION 3243 3472 AAA 5 (By similarity).
 REGION 3689 3904 AAA 6 (By similarity).  
Keyword
 ATP-binding; Cell membrane; Cell projection; Cilium; Cilium biogenesis/degradation; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Dynein; Membrane; Microtubule; Motor protein; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4306 AA 
Protein Sequence
MAGSLSDVRK LFLFTTTQNY FGLRPELWDQ TPLSNCPEVN NFLDDGNQML LRVQRSDAGL 60
AFSNTIDFDD TKDKVLVFFK LRPEVITDGN LHTNILVSSM LESPINSLYQ AVRQVFAPML 120
LKDQEWSRNF DPKLQNLLSE LEAGLGVVLR KSDTNLPKLK LKEDDTRGIL TPSDEFQFWI 180
EQAHRGSKQI SKERASYFKE LFETIAREFY NLDSLSLLEV VDLVETTRDV VDDVWRQAEH 240
DHYPESRMLH LLDVIGGSFG RFVQKKLGSL KLWEDPYYLV KENLKAGISI CEQWVIVCSH 300
LTGQVWQRYV PHPWKSEKYF PETLDRLGKR LEEVLAIRTI HEKLLYFLPA SEERIVCLSR 360
VFEPFTGVNP VQYNPYTEPL WKAAVSQYEK IIAPAEQKIA GKLKNYISEI QDSPQQLLQA 420
FLKYKELVKR PTISKELMLE RETLLARLGD SAKDFRLDFE NRCRGIPGDA SGPLSGKNLS 480
EVVNNIVWVR QLELKVDDTI KIAEALLSDL SGFRSFHRSA EDLLDQFKLY EQEQFDDWSR 540
EVQSGLSDSR SGLCIEANSR IMELDPNDGA LKVHYSDRLV ILLREVRQLS ALGFVIPAKI 600
QQVANVAQKF CKQAIILKQV AHFYNSIDQQ MIQSQRPMML QSALAFEQII KNSKAGSGGK 660
SQITWDNPKE LEGYIQKLQN AAERLATENR RLRKWHITFC EKVVILMNID LLRQQQRWKD 720
GLQELRTGLA SVAAQGFQPS DMRAWRQHWN HQLYKALEHQ YQMGLEALNE NLPEINVDLT 780
YKQGRLQFRP PFEEIRAKYY REMKRFIGIP NQFKGVGGAG DESIFSVMID RNASGFLTIY 840
SKAEDLFRRL SAVLHQHKEW VVIGQVDMEA LVEKNLSTVH DWEKNFKALK IKGKEVERLP 900
SAVKVDCLNI NCSPVKTVID DLIQKLFDLL VLSLKKSIQT HIHEIDTFVT EAMKVLTVIP 960
QSVEEIGDTN LQYSNLQDRR PEILPLFQEA EDKNRLLRTV AGGGVETVSN LRAKWDKFEL 1020
MMESHQLMIK DQIEVMKGNV KSRLQIYYQE LDKFKARWDQ LKPGDDIIET GQQNTMDQSA 1080
KSIKEKKIEF DDLEVIRKKL VDDCHHFGLE ESNFSLAYSI SKDIESCAQI WALYEEFQQG 1140
LQEMAKEDWI TYRTKIYIFE EFLINWHERL RKVEEHSVMT VKLQSEVDRY KIIIPILKYV 1200
RGEHLSPDHW LDLFRLLGLP RGTSLEKLLF GDLLRVADTI VEKASDLKDL NSRAQGEVTI 1260
REALRELDLW GVGAVFSLID YEDSQNRTIK LIKDWKDIVN QVGDNRCLLQ SLKDSPYYKG 1320
FEDKVSIWER KLAQLDEYLQ NLNHIQRKWV YLEPIFGRGA LPKEQTRFNK VDEDFRSIMM 1380
DIRKDSRVTT LTTHAGIRNT LLTILDQLQR CQKSLNEFLE EKRSAFPRFY FIGDDDLLEI 1440
LGQSTNPSVI QSHLKKLFAG INSVCFDEES KHITAMRSLE GEVVPFKSKV LLSNNVEAWL 1500
NDLALEMKQT LKQLLKECVT AGRSSQGAID PSLFPSQILC LAEQIKFTED VEDAIRDHSL 1560
HQIEAQLAAK LERYTSVDTS SEDPGNSESG ILELKLKTLI LDIIHNIDIV KQLNQAQVHT 1620
TDDWAWKKQV RFYMKSDHTC YVQMVDSELQ YTYEYQGNAP KLVYTPLTDK CYLTLTQAMK 1680
MGLGGNPYGP AGTGKTESVK ALGGLLGRQV LVFNCDEGID VKSMGRIFVG LVKCGAWGCF 1740
DEFNRLEEAV LSAVSMQIQT IQDALKNHRS VCELLGKEVE VNANSGIFIT MNPAGKGYGG 1800
RQKLPDNLKQ LFRPVAMSRP DNDLIAEVIL YSEGFKDAKE LGRKLVAIFN LSRELLTPQQ 1860
HYDWGLRALK TVLRGSGNLL RQLKKSGTKQ DVNENHIVVQ ALRLNTMSKF TFADCTRFDA 1920
LIKDVFPGID FKEVEYNELS SALKQVFEEA NYEVIPNQMK KALELYEQLR QRTGVVIVGP 1980
SGAGKSTLWR MLRAALCKIG KVVKQYTMNP KAMPRHQLLG HIDMDTREWS DGVLTNSARQ 2040
VVREPQDVSS WIICDGDIDP EWIESLNSVL DDNRLLTMPS GERIQFGPNV NFVFETHDLS 2100
CASPATISRM GMIFLSDEET DLNSLIKSWL RNQPVEYRSN LENWIGDYFS KALQWVLKQN 2160
DYVVETSLVG TVMNGLSHLH GCKYHDQFII NLIRGLGGNL NMKSRLEFTK EVFNWARETP 2220
PDSHRPMDTY FDCDRGQLAS YVLKKPESLT ADDFSSGHSL PVIQTPDMQR GLDYFKPWLS 2280
SETKQPFILV GPEGCGKGML LRYAFSQLRS TEIATIHCSA QTTSRHLLQK LSQTCMVIST 2340
NTGRVYRPKD CERLVLYLKD INLPKLDKWG TSTLVAFLQQ VLTYQGFYDE NLEWVGLENI 2400
QIVASMSAGG RLGRHKLTTR FTSIVRLCAV DYPEREQLQT IYGAYLEAVL HKNLKNHSIW 2460
GSSSKIYLLA GSMVQVYEQV RAKFTVDDYS HYFFTPCILT QWVLGLFRYD LEGGSSNHPL 2520
DYVLEVVAYE ARRLFRDKIV GVKELHLFDN ILTSVLQGDW GSDILDNMAD SFYVTWGAQH 2580
ISGAKIAPGQ PLPPHGKPLG KLSSADLKDV IKKGLIHYGR DNQNLDILLF QEVLEYMSRI 2640
DRVLSFPGGS LLLAGRSGVG RRTVTSLVSH MHGAVLFSPK ISRGYEPKQF RTDLKHVLHL 2700
AGIEAQQVVL LLEDYQFVHP TFLEMINSLL SSGEVPGLYT LEELEPLLLP LKDQASQDGF 2760
FGPVFNYFTY RIQQNLHIVL IMDSANLNFI INCESNPALH KKCRVLWMEG WSDSSMKKIP 2820
EMLFSEADIE EKYEKKRKDE KKKSSVDPDF IKSFLLIHES CKAYGATPSR YMTFLRVYSA 2880
ISSSKRKELL KRQSHLQAGV SKLNEAKALV DELNRKAGEQ SILLRIKQDE ADSALQEITV 2940
SMQDASEQKT ELERLKHRIA EEVVKIEERK SKIDDELKEV QPLVNEAKLA VGNIRPESLS 3000
EIRSLRMPPD VIRDILEGVL RLMGIFDTSW VSMKSFLAKR GVREDIATFD ARNIPKEIRE 3060
SVEELLFKNK ASFDPKNAKR ASTAAAPLAA WVKANVQYSH VLERIQPLET EQSGLELNLK 3120
KTEDRKRKLE DLLNSVGQKV SELKEKFQSR TSEAAKLEAE VSKAQETIKA AEVLISQLDR 3180
EHRRWNAQVA EIAEELATLP KRAQLAAAFI TYLSAAPEGL RKNCLEEWTK AAGLEKFDLR 3240
RFLCTESEQL IWKSEGLPSD DLSIENALVI LQSRVCPFLI DPSSQATEWL KTHLKDSHLE 3300
VINQQDSNFI TALELAVRFG KTLIIQEMDG VEPVLYPLLR RDLVAQGPRY VVQIGDKIID 3360
YNEDFRLFLS TRNPNPFIPP DAASIVTEVN FTTTRSGLRG QLLALTIQHE KPDLEEQKTK 3420
LLQQEEDKKI QLARLEESLL ETLATSQGNI LENKDLIESL NQTKASSALI QDSLKESYKL 3480
QISLDRERDA YLPLAESASK MYFIISDLSK INNMYRFSLA SFLRLFQRAL QNKQDSESTE 3540
QRIQCLVNSL KHMVYEYICR CLFKADQLMF ALHFVRGMHP EFFQENEWDT FTGVVVGDML 3600
RKADSQQRIR DQLPSWIDQE RSWAVATLKI SLPGLYQTLC FEDGTLWRTY YHHSMCEQEF 3660
PSILAKKVSL FQQVLVVQAL RPDRLQSAMA LFACKALGLK ELSPLPLNLK RLYKETLEIE 3720
PILIIISPGA DPSQELQELA NAERSSERYH QVAMGQGQAD LAIQMLKECA RNGDWLCLKN 3780
LHLVVSWLPV LEKELNTLQP KESFRLWLTA EVHPNFTPIL LQSSLKITYE SPPGLKKNLM 3840
RTYESWTPEQ ISKKDNIHRA HALFSLAWFH AACQERRNFI PQGWTKFYEF SLSDLRAGYH 3900
VIDRLFDGSK DVQWEFVHGL LENSIYGGRI DNYFDLRVLQ SYLKQFFNSS IIDVLNQRNK 3960
KSIFPYSISL PDSCSILDYR AVIEKLPEDD KPSFFGLPAN IARSSQRMTS SQVISQLRIL 4020
GRSVTAGCKF DREIWSNELS PVLNLWKKLN QNSNLIHQKV SPPNDRQGSP ILSFIILEQF 4080
NAIRLVQSVH QSLAALSKVI RGTTLLSSEV QKLASALLNQ KCPLTWQSKW EGPEDPLQYL 4140
RGLVARTLAI QNWVEKAEKQ ALLADTLDLS ELFHPDTFLN ALRQETARAT GCSVDSLKFV 4200
ASWKGRLQEA KLQIKISGLL LEGCSFDGSR LSENQHDSPS VSSVLPCYMG WTPQGSYGPY 4260
SPDECISLPV YTSAERDCVV TNIDVPCGGN QDQWIQCGAA LFLKNQ 4306 
Gene Ontology
 GO:0035085; C:cilium axoneme; IEA:UniProtKB-SubCell.
 GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0003777; F:microtubule motor activity; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; IEA:GOC.
 GO:0030031; P:cell projection assembly; IEA:InterPro.
 GO:0001539; P:ciliary or flagellar motility; IEA:InterPro.
 GO:0007018; P:microtubule-based movement; IEA:InterPro.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR011704; ATPase_dyneun-rel_AAA.
 IPR026983; DHC_fam.
 IPR026815; DYNC2H1.
 IPR024743; Dynein_HC_stalk.
 IPR024317; Dynein_heavy_chain_D4_dom.
 IPR004273; Dynein_heavy_dom.
 IPR013594; Dynein_heavy_dom-1.
 IPR013602; Dynein_heavy_dom-2.
 IPR027417; P-loop_NTPase. 
Pfam
 PF07728; AAA_5
 PF12780; AAA_8
 PF08385; DHC_N1
 PF08393; DHC_N2
 PF03028; Dynein_heavy
 PF12777; MT 
SMART
 SM00382; AAA 
PROSITE
  
PRINTS