UniProt Accession

 STX7_MOUSE; O70439 

Genbank Protein ID

 AF056323 

Genbank Nucleotide ID

 AAC15971.1 

Protein Name

 Syntaxin-7 

Protein Synonyms/Alias

  

Gene Name

 Stx7 

Gene Synonyms/Alias

 Syn7 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
24	RISSNIQKITQCSVE	ubiquitination	[1]
106	TSLTNFQKAQRQAAE	acetylation	[2]
106	TSLTNFQKAQRQAAE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379] 

Functional Description

 May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (By similarity). 

Sequence Annotation

 DOMAIN 165 227 t-SNARE coiled-coil homology.
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 45 45 Phosphoserine.
 MOD_RES 79 79 Phosphothreonine.
 MOD_RES 125 125 Phosphoserine.
 MOD_RES 126 126 Phosphoserine.
 MOD_RES 129 129 Phosphoserine.
 MOD_RES 205 205 Phosphoserine.  

Keyword

 3D-structure; Acetylation; Coiled coil; Complete proteome; Endosome; Iron; Membrane; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 261 AA 

Protein Sequence

Gene Ontology

 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI.
 GO:0031201; C:SNARE complex; IBA:RefGenome.
 GO:0005484; F:SNAP receptor activity; IBA:RefGenome.
 GO:0000149; F:SNARE binding; IBA:RefGenome.
 GO:0006886; P:intracellular protein transport; IBA:RefGenome.
 GO:0016079; P:synaptic vesicle exocytosis; IBA:RefGenome. 

Interpro

 IPR006012; Syntaxin/epimorphin_CS.
 IPR006011; Syntaxin_N.
 IPR010989; t-SNARE.
 IPR000727; T_SNARE_dom. 

Pfam

 PF05739; SNARE
 PF00804; Syntaxin 

SMART

 SM00503; SynN
 SM00397; t_SNARE 

PROSITE

 PS00914; SYNTAXIN
 PS50192; T_SNARE 

PRINTS