UniProt Accession

 A2AIM2_MOUSE; A2AIM2 

Genbank Protein ID

 AL732506 

Genbank Nucleotide ID

  

Protein Name

 Talin-1 

Protein Synonyms/Alias

  

Gene Name

 Tln1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
15	ISIGNVVKTMQFEPS	ubiquitination	[1]
196	ETLLLRRKFFYSDQN	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 241 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IEA:Compara.
 GO:0070062; C:extracellular vesicular exosome; IEA:Compara.
 GO:0005925; C:focal adhesion; IDA:MGI.
 GO:0043231; C:intracellular membrane-bounded organelle; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0007044; P:cell-substrate junction assembly; IMP:MGI.
 GO:0030866; P:cortical actin cytoskeleton organization; IMP:MGI.
 GO:0007016; P:cytoskeletal anchoring at plasma membrane; IEA:InterPro. 

Interpro

 IPR019749; Band_41_domain.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
 IPR019748; FERM_central.
 IPR019747; FERM_CS.
 IPR000299; FERM_domain.
 IPR018979; FERM_N.
 IPR015710; Talin-1. 

Pfam

 PF00373; FERM_M
 PF09379; FERM_N 

SMART

 SM00295; B41 

PROSITE

 PS00660; FERM_1
 PS50057; FERM_3 

PRINTS