CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015081
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein phosphatase 4 regulatory subunit 4 
Protein Synonyms/Alias
  
Gene Name
 PPP4R4 
Gene Synonyms/Alias
 KIAA1622; PP4R4 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
852TGNSVDPKSSGSKDTacetylation[1]
857DPKSSGSKDTQPRKAacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Putative regulatory subunit of serine/threonine-protein phosphatase 4. 
Sequence Annotation
 REPEAT 213 251 HEAT 1.
 REPEAT 252 290 HEAT 2.
 REPEAT 392 427 HEAT 3.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 873 AA 
Protein Sequence
MHPPPPAAAM DFSQNSLFGY MEDLQELTII ERPVRRSLKT PEEIERLTVD EDLSDIERAV 60
YLLSAGQDVQ GTSVIANLPF LMRQNPTETL RRVLPKVREA LHVAGVEMQL TAAMSFLTIL 120
QDESVSIHAY THSFLQVILL HLEHRDTGVS NAWLETLLSV IEVLPKETLR HEILNPLVSK 180
AQLSQTVQSR LVSCKILGKL TNKFDAHTIK REILPLVKSL CQDVEYEVRS CMCRQLENIA 240
QGIGTELTKS VVLPELIELS RDEGSSVRLA AFETLVNLLD IFDTDDRSQT ILPLVKSFCE 300
KSFKADESIL ISLSFHLGKL CHGLYGIFTP DQHLRFLEFY KKLCTLGLQQ ENGHNENQIP 360
PQILEQEKKY ISVRKNCAYN FPAMIVFVDP KNFHMELYST FFCLCHDPEV PVRYTIAICF 420
YEVSKLLNSG VYLIHKELIT LLQDESLEVL DALIDHLPEI LELMSTGGES SVQENKLSSL 480
PDLIPALTAA EQRAAASLKW RTHEKLLQKY ACLPHVISSD QIYYRFLQRM FTIMMTNNVL 540
PVQKAASRTL CIFLRYNRKQ EQRHEVIQKL IEQLGQGKSY WNRLRFLDTC EFIIEIFSKS 600
FFCKYFFLPA IELTHDPVAN VRMKLCYLLP KVKSTLKIPA DKHLLQQLEM CVRKLLCQEK 660
DKDVLAIVKR TVLELDRMEM SMDAFQKKFY EKDLLDQEKE REELLLLEME QLEKEKQQND 720
GRPMSDKMFE KKRRDTKTPT QSLPKNIPIS VPGPSSVTPS TSKEIKKSKL IRSQSFNNQA 780
FHAKYGNLEK CASKSSTTGY TTSVSGLGKT SVLSLADDSF RTRNASSVPS SFSPNTPLPS 840
TSRGTGNSVD PKSSGSKDTQ PRKATLKSRK SNP 873 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0008287; C:protein serine/threonine phosphatase complex; IDA:UniProtKB.
 GO:0019888; F:protein phosphatase regulator activity; IDA:MGI.
 GO:0032515; P:negative regulation of phosphoprotein phosphatase activity; IDA:MGI.
 GO:0080163; P:regulation of protein serine/threonine phosphatase activity; IDA:MGI. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR021133; HEAT_type_2. 
Pfam
  
SMART
  
PROSITE
 PS50077; HEAT_REPEAT 
PRINTS