CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022056
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Matrix-remodeling-associated protein 5 
Protein Synonyms/Alias
 Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan; Adlican 
Gene Name
 MXRA5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
243RGILKCKKDKAYEGGubiquitination[1]
245ILKCKKDKAYEGGQLubiquitination[1]
260CAMCFSPKKLYKHEIubiquitination[1]
1336DVATNVDKHKSDILVacetylation[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
  
Sequence Annotation
 DOMAIN 27 55 LRRNT.
 REPEAT 56 77 LRR 1.
 REPEAT 80 101 LRR 2.
 REPEAT 104 125 LRR 3.
 REPEAT 128 149 LRR 4.
 REPEAT 152 173 LRR 5.
 REPEAT 184 205 LRR 6.
 DOMAIN 217 277 LRRCT.
 DOMAIN 481 571 Ig-like C2-type 1.
 DOMAIN 575 669 Ig-like C2-type 2.
 REPEAT 1410 1434 LRR 7.
 DOMAIN 1853 1946 Ig-like C2-type 3.
 DOMAIN 1950 2041 Ig-like C2-type 4.
 DOMAIN 2046 2140 Ig-like C2-type 5.
 DOMAIN 2146 2239 Ig-like C2-type 6.
 DOMAIN 2242 2343 Ig-like C2-type 7.
 DOMAIN 2345 2432 Ig-like C2-type 8.
 DOMAIN 2440 2534 Ig-like C2-type 9.
 DOMAIN 2542 2630 Ig-like C2-type 10.
 DOMAIN 2637 2722 Ig-like C2-type 11.
 DOMAIN 2733 2828 Ig-like C2-type 12.
 CARBOHYD 287 287 N-linked (GlcNAc...) (Potential).
 CARBOHYD 321 321 N-linked (GlcNAc...) (Potential).
 CARBOHYD 633 633 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1403 1403 N-linked (GlcNAc...) (Potential).
 CARBOHYD 1735 1735 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2007 2007 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2056 2056 N-linked (GlcNAc...) (Potential).
 CARBOHYD 2693 2693 N-linked (GlcNAc...) (Potential).
 DISULFID 501 555 By similarity.
 DISULFID 599 651 By similarity.
 DISULFID 1875 1928 By similarity.
 DISULFID 1972 2025 By similarity.
 DISULFID 2069 2122 By similarity.
 DISULFID 2168 2221 By similarity.
 DISULFID 2265 2324 By similarity.
 DISULFID 2368 2418 By similarity.
 DISULFID 2466 2518 By similarity.
 DISULFID 2564 2616 By similarity.
 DISULFID 2659 2711 By similarity.
 DISULFID 2755 2810 By similarity.  
Keyword
 Complete proteome; Disulfide bond; Glycoprotein; Leucine-rich repeat; Polymorphism; Reference proteome; Repeat; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2828 AA 
Protein Sequence
MPKRAHWGAL SVVLILLWGH PRVALACPHP CACYVPSEVH CTFRSLASVP AGIAKHVERI 60
NLGFNSIQAL SETSFAGLTK LELLMIHGNE IPSIPDGALR DLSSLQVFKF SYNKLRVITG 120
QTLQGLSNLM RLHIDHNKIE FIHPQAFNGL TSLRLLHLEG NLLHQLHPST FSTFTFLDYF 180
RLSTIRHLYL AENMVRTLPA SMLRNMPLLE NLYLQGNPWT CDCEMRWFLE WDAKSRGILK 240
CKKDKAYEGG QLCAMCFSPK KLYKHEIHKL KDMTCLKPSI ESPLRQNRSR SIEEEQEQEE 300
DGGSQLILEK FQLPQWSISL NMTDEHGNMV NLVCDIKKPM DVYKIHLNQT DPPDIDINAT 360
VALDFECPMT RENYEKLWKL IAYYSEVPVK LHRELMLSKD PRVSYQYRQD ADEEALYYTG 420
VRAQILAEPE WVMQPSIDIQ LNRRQSTAKK VLLSYYTQYS QTISTKDTRQ ARGRSWVMIE 480
PSGAVQRDQT VLEGGPCQLS CNVKASESPS IFWVLPDGSI LKAPMDDPDS KFSILSSGWL 540
RIKSMEPSDS GLYQCIAQVR DEMDRMVYRV LVQSPSTQPA EKDTVTIGKN PGESVTLPCN 600
ALAIPEAHLS WILPNRRIIN DLANTSHVYM LPNGTLSIPK VQVSDSGYYR CVAVNQQGAD 660
HFTVGITVTK KGSGLPSKRG RRPGAKALSR VREDIVEDEG GSGMGDEENT SRRLLHPKDQ 720
EVFLKTKDDA INGDKKAKKG RRKLKLWKHS EKEPETNVAE GRRVFESRRR INMANKQINP 780
ERWADILAKV RGKNLPKGTE VPPLIKTTSP PSLSLEVTPP FPAISPPSAS PVQTVTSAEE 840
SSADVPLLGE EEHVLGTISS ASMGLEHNHN GVILVEPEVT STPLEEVVDD LSEKTEEITS 900
TEGDLKGTAA PTLISEPYEP SPTLHTLDTV YEKPTHEETA TEGWSAADVG SSPEPTSSEY 960
EPPLDAVSLA ESEPMQYFDP DLETKSQPDE DKMKEDTFAH LTPTPTIWVN DSSTSQLFED 1020
STIGEPGVPG QSHLQGLTDN IHLVKSSLST QDTLLIKKGM KEMSQTLQGG NMLEGDPTHS 1080
RSSESEGQES KSITLPDSTL GIMSSMSPVK KPAETTVGTL LDKDTTTATT TPRQKVAPSS 1140
TMSTHPSRRR PNGRRRLRPN KFRHRHKQTP PTTFAPSETF STQPTQAPDI KISSQVESSL 1200
VPTAWVDNTV NTPKQLEMEK NAEPTSKGTP RRKHGKRPNK HRYTPSTVSS RASGSKPSPS 1260
PENKHRNIVT PSSETILLPR TVSLKTEGPY DSLDYMTTTR KIYSSYPKVQ ETLPVTYKPT 1320
SDGKEIKDDV ATNVDKHKSD ILVTGESITN AIPTSRSLVS TMGEFKEESS PVGFPGTPTW 1380
NPSRTAQPGR LQTGIPVTTS GENLTDPPLL KELEDVDFTS EFLSSLTVST PFHQEEAGSS 1440
TTLSSIKVEV ASSQAETTTL DQDHLETTVA ILLSETRPQN HTPTAARMKE PASSSPSTIL 1500
MSLGQTTTTK PALPSPRISQ ASRDSKENVF LNYVGNPETE ATPVNNEGTQ HMSGPNELST 1560
PSSDQDAFNL STKLELEKQV FGSRSLPRGP DSQRQDGRVH ASHQLTRVPA KPILPTATVR 1620
LPEMSTQSAS RYFVTSQSPR HWTNKPEITT YPSGALPENK QFTTPRLSST TIPLPLHMSK 1680
PSIPSKFTDR RTDQFNGYSK VFGNNNIPEA RNPVGKPPSP RIPHYSNGRL PFFTNKTLSF 1740
PQLGVTRRPQ IPTSPAPVMR ERKVIPGSYN RIHSHSTFHL DFGPPAPPLL HTPQTTGSPS 1800
TNLQNIPMVS STQSSISFIT SSVQSSGSFH QSSSKFFAGG PPASKFWSLG EKPQILTKSP 1860
QTVSVTAETD TVFPCEATGK PKPFVTWTKV STGALMTPNT RIQRFEVLKN GTLVIRKVQV 1920
QDRGQYMCTA SNLHGLDRMV VLLSVTVQQP QILASHYQDV TVYLGDTIAM ECLAKGTPAP 1980
QISWIFPDRR VWQTVSPVEG RITLHENRTL SIKEASFSDR GVYKCVASNA AGADSLAIRL 2040
HVAALPPVIH QEKLENISLP PGLSIHIHCT AKAAPLPSVR WVLGDGTQIR PSQFLHGNLF 2100
VFPNGTLYIR NLAPKDSGRY ECVAANLVGS ARRTVQLNVQ RAAANARITG TSPRRTDVRY 2160
GGTLKLDCSA SGDPWPRILW RLPSKRMIDA LFSFDSRIKV FANGTLVVKS VTDKDAGDYL 2220
CVARNKVGDD YVVLKVDVVM KPAKIEHKEE NDHKVFYGGD LKVDCVATGL PNPEISWSLP 2280
DGSLVNSFMQ SDDSGGRTKR YVVFNNGTLY FNEVGMREEG DYTCFAENQV GKDEMRVRVK 2340
VVTAPATIRN KTYLAVQVPY GDVVTVACEA KGEPMPKVTW LSPTNKVIPT SSEKYQIYQD 2400
GTLLIQKAQR SDSGNYTCLV RNSAGEDRKT VWIHVNVQPP KINGNPNPIT TVREIAAGGS 2460
RKLIDCKAEG IPTPRVLWAF PEGVVLPAPY YGNRITVHGN GSLDIRSLRK SDSVQLVCMA 2520
RNEGGEARLI LQLTVLEPME KPIFHDPISE KITAMAGHTI SLNCSAAGTP TPSLVWVLPN 2580
GTDLQSGQQL QRFYHKADGM LHISGLSSVD AGAYRCVARN AAGHTERLVS LKVGLKPEAN 2640
KQYHNLVSII NGETLKLPCT PPGAGQGRFS WTLPNGMHLE GPQTLGRVSL LDNGTLTVRE 2700
ASVFDRGTYV CRMETEYGPS VTSIPVIVIA YPPRITSEPT PVIYTRPGNT VKLNCMAMGI 2760
PKADITWELP DKSHLKAGVQ ARLYGNRFLH PQGSLTIQHA TQRDAGFYKC MAKNILGSDS 2820
KTTYIHVF 2828 
Gene Ontology
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. 
Interpro
 IPR000483; Cys-rich_flank_reg_C.
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR013098; Ig_I-set.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR000372; LRR-contain_N. 
Pfam
 PF07679; I-set 
SMART
 SM00409; IG
 SM00408; IGc2
 SM00369; LRR_TYP
 SM00082; LRRCT
 SM00013; LRRNT 
PROSITE
 PS50835; IG_LIKE 
PRINTS