UniProt Accession

 PRI2_HUMAN; P49643; Q53FJ8; Q6P1Q7; Q8WVL2; Q9H413 

Genbank Protein ID

 X74331; AL121975; AL162579; AL162579; AL121975; BC017833; BC064931 

Genbank Nucleotide ID

 CAA52378.1; CAI20534.1; CAI20534.1; CAH73686.1; CAH73686.1; AAH17833.1; AAH64931.1 

Protein Name

 DNA primase large subunit 

Protein Synonyms/Alias

 DNA primase 58 kDa subunit; p58 

Gene Name

 PRIM2 

Gene Synonyms/Alias

 PRIM2A 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
65	NLGVSYVKGTEQYQS	ubiquitination	[1]
73	GTEQYQSKLESELRK	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. 

Sequence Annotation

 METAL 287 287 Iron-sulfur (4Fe-4S).
 METAL 367 367 Iron-sulfur (4Fe-4S).
 METAL 384 384 Iron-sulfur (4Fe-4S).
 METAL 424 424 Iron-sulfur (4Fe-4S).  

Keyword

 3D-structure; 4Fe-4S; Alternative splicing; Complete proteome; DNA replication; DNA-binding; DNA-directed RNA polymerase; Iron; Iron-sulfur; Metal-binding; Nucleotidyltransferase; Polymorphism; Primosome; Reference proteome; Transcription; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 509 AA 

Protein Sequence

Gene Ontology

 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:1990077; C:primosome complex; IEA:UniProtKB-KW.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003896; F:DNA primase activity; TAS:ProtInc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006270; P:DNA replication initiation; TAS:Reactome.
 GO:0006271; P:DNA strand elongation involved in DNA replication; TAS:Reactome.
 GO:0000082; P:G1/S transition of mitotic cell cycle; TAS:Reactome.
 GO:0000722; P:telomere maintenance via recombination; TAS:Reactome.
 GO:0032201; P:telomere maintenance via semi-conservative replication; TAS:Reactome. 

Interpro

 IPR016558; DNA_primase_lsu_euk.
 IPR007238; DNA_primase_lsu_euk/arc. 

Pfam

 PF04104; DNA_primase_lrg 

SMART

  

PROSITE

  

PRINTS