CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032260
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SART3 protein 
Protein Synonyms/Alias
 Squamous cell carcinoma antigen recognized by T-cells 3 
Gene Name
 SART3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
130RLEGELTKVRMARQKubiquitination[1]
294KALQQLEKYKPYEEAubiquitination[1, 2]
455RLCNNMQKARELWDSubiquitination[1]
532DWDIAVQKTETRLARacetylation[3]
532DWDIAVQKTETRLARubiquitination[1, 4, 5]
550QRMKAAEKEAALVQQubiquitination[1]
831KMDGMTIKENIIKVAubiquitination[1]
922MSNADFAKLFLRK**ubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 927 AA 
Protein Sequence
MATAAETSAS EPEAESKAGP KADGEEDEVK AARTRRKVLS RAVAAATYKT MGPAWDQQEE 60
GVSESDGDEY AMASSAESSP GEYEWEYDEE EEKNQLEIER LEEQLSINVY DYNCHVDLIR 120
LLRLEGELTK VRMARQKMSE IFPLTEELWL EWLHDEISMA QDGLDREHVY DLFEKAVKDY 180
ICPNIWLEYG QYSVGGIGQK GGLEKVRSVF ERALSSVGLH MTKGLALWEA YREFESAIVE 240
AARLEKVHSL FRRQLAIPLY DMEATFAEYE EWSEDPIPES VIQNYNKALQ QLEKYKPYEE 300
ALLQAEAPRL AEYQAYIDFE MKIGDPARIQ LIFERALVEN CLVPDLWIRY SQYLDRQLKV 360
KDLVLSVHNR AIRNCPWTVA LWSRYLLAME RHGVDHQVIS DSSKELEELR AAFTRALEYL 420
KQEVEERFNE SGDPSCVIMQ NWARIEARLC NNMQKARELW DSIMTRGNAK YANMWLEYYN 480
LERAHGDTQH CRKALHRAVQ CTSDYPEHVC EVLLTMERTE GSLEDWDIAV QKTETRLARV 540
NEQRMKAAEK EAALVQQEEE KAEQRKRARA EKKALKKKKK IRGPEKRGAD EDDEKEWGDD 600
EEEQPSKRRR VENSIPAAGE TQNVEVAAGP AGKCAAVDVE PPSKQKEKAA SLKRDMPKVL 660
HDSSKDSITV FVSNLPYSMQ EPDTKLRPLF EACGEVVQIR PIFSNRGDFR GYCYVEFKEE 720
KSALQALEMD RKSVEGRPMF VSPCVDKSKN PDFKVFRYST SLEKHKLFIS GLPFSCTKEE 780
LEEICKAHGT VKDLRLVTNR AGKPKGLAYV EYENESQASQ AVMKMDGMTI KENIIKVAIS 840
NPPQRKVPEK PETRKAPGGP MLLPQTYGAR GKGRTQLSLL PRALQRPSAA APQAENGPAA 900
APAVAAPAAT EAPKMSNADF AKLFLRK 927 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0006396; P:RNA processing; IEA:InterPro. 
Interpro
 IPR003107; HAT.
 IPR008669; LSM_interact.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF05391; Lsm_interact
 PF00076; RRM_1 
SMART
 SM00386; HAT
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS