| Tag | Content |
|---|
| CPLM ID | CPLM-001693 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Probable tubulin polyglutamylase TTLL1 |
Protein Synonyms/Alias | Tubulin polyglutamylase complex subunit 3; PGs3; Tubulin--tyrosine ligase-like protein 1 |
Gene Name | TTLL1 |
Gene Synonyms/Alias | C22orf7 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 138 | PSSTWIMKPCGKAQG | ubiquitination | [1] | | 146 | PCGKAQGKGIFLINK | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Catalytic subunit of the neuronal tubulin polyglutamylase complex. Modifies alpha- and beta-tubulin, generating side chains of glutamate on the gamma-carboxyl groups of specific glutamate residues within the C-terminal tail of alpha- and beta-tubulin (By similarity). |
Sequence Annotation | DOMAIN 1 367 TTL. |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Ligase; Microtubule; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 423 AA |
Protein Sequence | MAGKVKWVTD IEKSVLINNF EKRGWVQVTE NEDWNFYWMS VQTIRNVFSV EAGYRLSDDQ 60
IVNHFPNHYE LTRKDLMVKN IKRYRKELEK EGSPLAEKDE NGKYLYLDFV PVTYMLPADY 120
NLFVEEFRKS PSSTWIMKPC GKAQGKGIFL INKLSQIKKW SRDSKTSSFV SQSNKEAYVI 180
SLYINNPLLI GGRKFDLRLY VLVSTYRPLR CYMYKLGFCR FCTVKYTPST SELDNMFVHL 240
TNVAIQKHGE DYNHIHGGKW TVSNLRLYLE STRGKEVTSK LFDEIHWIIV QSLKAVAPVM 300
NNDKHCFECY GYDIIIDDKL KPWLIEVNAS PSLTSSTAND RILKYNLIND TLNIAVPNGE 360
IPDCKWNKSP PKEVLGNYEI LYDEELAQGD GADRELRSRQ GQSLGPRAGR SRDSGRAVLT 420
TWK 423 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. GO:0005874; C:microtubule; IEA:UniProtKB-KW. GO:0070740; F:tubulin-glutamic acid ligase activity; TAS:UniProtKB. GO:0004835; F:tubulin-tyrosine ligase activity; IEA:InterPro. GO:0035083; P:cilium axoneme assembly; IEA:Compara. GO:0003351; P:epithelial cilium movement; IEA:Compara. GO:0018095; P:protein polyglutamylation; TAS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |