UniProt Accession

 LGR4_MOUSE; A2ARI4; A2ARI3; Q6PHA3; Q80T31; Q8BXS9 

Genbank Protein ID

 AL845423; AL928922; AL928922; AL845423; BX294391; AY255619; AK044357; BC056637 

Genbank Nucleotide ID

 CAM17466.1; CAM17466.1; CAM24131.1; CAM24131.1; AAO85131.1; BAC31882.1; AAH56637.1 

Protein Name

 Leucine-rich repeat-containing G-protein coupled receptor 4 

Protein Synonyms/Alias

 G-protein coupled receptor 48 

Gene Name

 Lgr4 

Gene Synonyms/Alias

 Gpr48 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
108	LSGLKELKVLTLQNN	acetylation	[1]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. 

Sequence Annotation

 DOMAIN 25 57 LRRNT.
 REPEAT 58 79 LRR 1.
 REPEAT 82 103 LRR 2.
 REPEAT 106 127 LRR 3.
 REPEAT 130 151 LRR 4.
 REPEAT 154 177 LRR 5.
 REPEAT 178 199 LRR 6.
 REPEAT 202 223 LRR 7.
 REPEAT 226 247 LRR 8.
 REPEAT 249 270 LRR 9.
 REPEAT 273 294 LRR 10.
 REPEAT 320 341 LRR 11.
 REPEAT 344 365 LRR 12.
 REPEAT 366 387 LRR 13.
 REPEAT 390 411 LRR 14.
 REPEAT 414 435 LRR 15.
 CARBOHYD 68 68 N-linked (GlcNAc...) (Potential).
 CARBOHYD 188 188 N-linked (GlcNAc...) (Potential).
 CARBOHYD 199 199 N-linked (GlcNAc...) (Potential).
 CARBOHYD 294 294 N-linked (GlcNAc...) (Potential).
 CARBOHYD 505 505 N-linked (GlcNAc...) (Potential).
 DISULFID 618 693 By similarity.  

Keyword

 Alternative splicing; Cell membrane; Complete proteome; Developmental protein; Differentiation; Disulfide bond; G-protein coupled receptor; Glycoprotein; Immunity; Innate immunity; Leucine-rich repeat; Membrane; Receptor; Reference proteome; Repeat; Signal; Spermatogenesis; Transducer; Transmembrane; Transmembrane helix; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 951 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0016500; F:protein-hormone receptor activity; IEA:InterPro.
 GO:0061290; P:canonical Wnt receptor signaling pathway involved in metanephric kidney development; IMP:UniProtKB.
 GO:0072202; P:cell differentiation involved in metanephros development; IMP:UniProtKB.
 GO:0050673; P:epithelial cell proliferation; IMP:MGI.
 GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
 GO:0030539; P:male genitalia development; IMP:MGI.
 GO:0072224; P:metanephric glomerulus development; IMP:UniProtKB.
 GO:0072282; P:metanephric nephron tubule morphogenesis; IMP:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:UniProtKB.
 GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IMP:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:UniProtKB.
 GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW. 

Interpro

 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM.
 IPR002131; Gphrmn_rcpt.
 IPR001611; Leu-rich_rpt.
 IPR003591; Leu-rich_rpt_typical-subtyp.
 IPR000372; LRR-contain_N. 

Pfam

 PF00001; 7tm_1
 PF00560; LRR_1
 PF01462; LRRNT 

SMART

 SM00369; LRR_TYP
 SM00013; LRRNT 

PROSITE

 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2
 PS51450; LRR 

PRINTS

 PR00373; GLYCHORMONER.
 PR00237; GPCRRHODOPSN.