| Tag | Content |
|---|
| CPLM ID | CPLM-008570 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Peroxisome proliferation transcriptional regulator |
Protein Synonyms/Alias | Oleate-activated transcription factor 2 |
Gene Name | PIP2 |
Gene Synonyms/Alias | OAF2; YOR363C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 100 | KDFYTALKRPTEELA | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | The PIP2-OAF1 heterodimer acts as a transcriptional activator to induce the transcription of genes encoding proteins involved in fatty acid beta-oxidation, a response called oleic acid induction, when cells grow on fatty acids as sole carbon source. Recognizes and binds to the oleate response element (ORE) (or peroxisome box), two inverted CGG triplets spaced by 14 to 18 intervening nucleotides, in the promoter region of a number of genes (such as CTA1, FOX1 to FOX3, FAA2, PAS8, PAS10, etc.) for peroxisomal proteins. Activity is inhibited by OAF1 under non- inducing conditions. Activity is repressed by glucose. |
Sequence Annotation | DNA_BIND 25 52 Zn(2)-C6 fungal-type.
MOTIF 985 993 9aaTAD. |
Keyword | Activator; Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription; Transcription regulation; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 996 AA |
Protein Sequence | MYFTDESSPA MNRVGKKRNR LSFVCQACRK AKTKCDQEKP RCGRCTKQNL FCIYDVARQA 60
APRNPNKDAT IARLKKEIRY WRNKTVDLTQ EKKDFYTALK RPTEELAARR TCKSLQENSF 120
PISLYKTHPR LIMTKVMKRE INPLSEKYLI FQDTFLKTLI ASVLLSCSRN SMIPALNADI 180
SRSRTQPCVK NNVVKMREVL LKNSKYESQR KSINEFTDRL LQRKNPEEQI AVNKVISLLY 240
SNRESSYLED TCPTENDYSD LLKGYINEIE KTLPPKAIIE QYLSHFFEHI FHLIPFASKE 300
MLEESIHTTV QYNELGEVRL SMGTTLIRNK MENLCILLLI LRIAYISLTF IEDKIEDYSP 360
YITKEMLEQY PIQSEVIFLA QQILASENWC ACANENTISC LLYIWCAFVF SPTEGDFLLE 420
QPSDVIINLV ILIGTSIGLH RDPSDFPALN HPEASDKRLL NLRRIQWLSI ISMATLESSL 480
KGRLLVSPLS MIDLFIDVRD PNCVEIYKKR VKKDLTGSES DEQLLEIHEI FFHRAQLALF 540
LSDLNNITIS YSGSVPMDTL ETLRVKANEL LKNKFQLRSV DINIYDEEKT FQKLTFNSIL 600
NSISLSGQIL GKLMMLRASI ALMLYFETLA MERSECLSFF YKYFFQCCAD TISLIRFFFL 660
YFNGSYEKVL SSLVCFITTK VIQLAVPTTM FTLLVIIMRV ELAKNMLLVK CNECNARGDI 720
SDLPEIKEKI KSLDTIKENF ERLLLEVYLL ASQNLRFKYF YIFKMLTLFD VFIQRLRKGQ 780
LFSGLFVKVD KDLTTKKIAT MLELTLGINL DKSDHLIDRL KGKNLTVNFT LDQLYQIIKE 840
FDRIKNIGVA DPQNSLNPSK PNMKDNTPTI ELLLNSSVEN ESVPPYSSSN DPTNVGNAST 900
YSLAHNISNQ NNEENMPPSI GSSESNRAAP NLNFMPINNN YNNSGSNINN NDNVKLPSNF 960
KNYYDPPMSS LDISMDVPDI FGSLDFFDYD LLFQND 996 |
Gene Ontology | GO:0016021; C:integral to membrane; ISM:SGD. GO:0005634; C:nucleus; IPI:SGD. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:SGD. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0071400; P:cellular response to oleic acid; IPI:SGD. GO:0032000; P:positive regulation of fatty acid beta-oxidation; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |