UniProt Accession

 RS4Y1_HUMAN; P22090; A8K9V4 

Genbank Protein ID

 M58459; AF041427; AF116711; AK292819; CH471115; BC010286 

Genbank Nucleotide ID

 AAA63256.1; AAB96967.1; AAF71131.1; BAF85508.1; EAX02771.1; AAH10286.1 

Protein Name

 40S ribosomal protein S4, Y isoform 1 

Protein Synonyms/Alias

  

Gene Name

 RPS4Y1 

Gene Synonyms/Alias

 RPS4Y; PRO2646 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
16	LKRVAAPKHWMLDKL	ubiquitination	[1]
22	PKHWMLDKLTGVFAP	acetylation	[2]
22	PKHWMLDKLTGVFAP	ubiquitination	[1]
37	RPSTGPHKLRECLPL	ubiquitination	[1]
53	VFLRNRLKYALTGDE	ubiquitination	[1]
63	LTGDEVKKICMQRFI	ubiquitination	[1]
71	ICMQRFIKIDGKVRV	ubiquitination	[1]
75	RFIKIDGKVRVDVTY	ubiquitination	[1]
106	FRLVYDTKGRFAVHR	ubiquitination	[1]
120	RITVEEAKYKLCKVR	ubiquitination	[1]
125	EAKYKLCKVRKITVG	ubiquitination	[1]
134	RKITVGVKGIPHLVT	ubiquitination	[1, 3]
168	QIDLGTGKIINFIKF	ubiquitination	[1, 3]
211	SFDVVHVKDANGNSF	ubiquitination	[1]
233	FVIGNGNKPWISLPR	ubiquitination	[1, 3, 4]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

  

Sequence Annotation

 DOMAIN 42 104 S4 RNA-binding.  

Keyword

 Complete proteome; Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 263 AA 

Protein Sequence

Gene Ontology

 GO:0022627; C:cytosolic small ribosomal subunit; NAS:UniProtKB.
 GO:0005844; C:polysome; IDA:UniProtKB.
 GO:0003723; F:RNA binding; TAS:ProtInc.
 GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
 GO:0003735; F:structural constituent of ribosome; IMP:UniProtKB.
 GO:0007275; P:multicellular organismal development; IMP:UniProtKB.
 GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
 GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
 GO:0006414; P:translational elongation; TAS:Reactome.
 GO:0006413; P:translational initiation; TAS:Reactome.
 GO:0006415; P:translational termination; TAS:Reactome.
 GO:0019083; P:viral transcription; TAS:Reactome. 

Interpro

 IPR005824; KOW.
 IPR000876; Ribosomal_S4e.
 IPR013845; Ribosomal_S4e_central_region.
 IPR013843; Ribosomal_S4e_N.
 IPR018199; Ribosomal_S4e_N_CS.
 IPR002942; S4_RNA-bd. 

Pfam

 PF00467; KOW
 PF00900; Ribosomal_S4e
 PF08071; RS4NT
 PF01479; S4 

SMART

 SM00363; S4 

PROSITE

 PS00528; RIBOSOMAL_S4E
 PS50889; S4 

PRINTS