UniProt Accession

 ABHDB_HUMAN; Q8NFV4; H7BYM8; Q6PJU0; Q8N722; Q8N723; Q8NFV2; Q8NFV3; Q9HBS8 

Genbank Protein ID

 AF412030; AF412031; AF412032; AY053499; AY053500; AC073846; BC008251; BC011712; BC067750; AF217971 

Genbank Nucleotide ID

 AAM62312.1; AAM62313.1; AAM62314.1; AAL14848.1; AAL14849.1; AAS07472.1; AAH08251.2; AAH11712.1; AAH67750.1; AAG17214.1 

Protein Name

 Alpha/beta hydrolase domain-containing protein 11 

Protein Synonyms/Alias

 Abhydrolase domain-containing protein 11; Williams-Beuren syndrome chromosomal region 21 protein 

Gene Name

 ABHD11 

Gene Synonyms/Alias

 WBSCR21; PP1226 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
87	TNFNSIAKILAQQTG	acetylation	[1]
87	TNFNSIAKILAQQTG	ubiquitination	[2, 3]
200	LPRSRARKLADEQLS	ubiquitination	[4]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

 ACT_SITE 141 141 Charge relay system (By similarity).
 ACT_SITE 237 237 Charge relay system (By similarity).
 ACT_SITE 296 296 Charge relay system (By similarity).  

Keyword

 Alternative splicing; Complete proteome; Hydrolase; Reference proteome; Williams-Beuren syndrome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 315 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW. 

Interpro

 IPR000073; AB_hydrolase_1. 

Pfam

  

SMART

  

PROSITE

  

PRINTS

 PR00111; ABHYDROLASE.