| Tag | Content |
|---|
| CPLM ID | CPLM-000155 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sodium channel protein type 9 subunit alpha |
Protein Synonyms/Alias | Peripheral sodium channel 1; PN1; Sodium channel protein type IX subunit alpha; Voltage-gated sodium channel subunit alpha Nav1.7 |
Gene Name | Scn9a |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 31 | EQRISEEKAKEHKDE | acetylation | [1] | | 33 | RISEEKAKEHKDEKK | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain (By similarity). |
Sequence Annotation | REPEAT 121 405 I.
REPEAT 737 968 II.
REPEAT 1185 1456 III.
REPEAT 1508 1759 IV.
DOMAIN 1887 1916 IQ.
CARBOHYD 209 209 N-linked (GlcNAc...) (Potential).
CARBOHYD 283 283 N-linked (GlcNAc...) (Potential).
CARBOHYD 1350 1350 N-linked (GlcNAc...) (Potential).
CARBOHYD 1364 1364 N-linked (GlcNAc...) (Potential).
CARBOHYD 1373 1373 N-linked (GlcNAc...) (Potential). |
Keyword | Complete proteome; Direct protein sequencing; Glycoprotein; Ion channel; Ion transport; Membrane; Reference proteome; Repeat; Sodium; Sodium channel; Sodium transport; Transmembrane; Transmembrane helix; Transport; Ubl conjugation; Voltage-gated channel. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1984 AA |
Protein Sequence | MAMLPPPGPQ SFVHFTKQSL ALIEQRISEE KAKEHKDEKK DDEEEGPKPS SDLEAGKQLP 60
FIYGDIPPGM VSEPLEDLDP YYADKKTFIV LNKGKAIFRF NATPALYMLS PFSPLRRISI 120
KILVHSLFSM LIMCTILTNC IFMTLSNPPE WTKNVEYTFT GIYTFESLIK ILARGFCVGE 180
FTFLRDPWNW LDFVVIVFAY LTEFVNLGNV SALRTFRVLR ALKTISVIPG LKTIVGALIQ 240
SVKKLSDVMI LTVFCLSVFA LIGLQLFMGN LKHKCFRKEL EENETLESIM NTAESEEELK 300
KYFYYLEGSK DALLCGFSTD SGQCPEGYIC VKAGRNPDYG YTSFDTFSWA FLALFRLMTQ 360
DYWENLYQQT LRAAGKTYMI FFVVVIFLGS FYLINLILAV VAMAYEEQNQ ANIEEAKQKE 420
LEFQQMLDRL KKEQEEAEAI AAAAAEFTSI GRSRIMGLSE SSSETSRLSS KSAKERRNRR 480
KKKKQKMSSG EEKGDDEKLS KSGSEESIRK KSFHLGVEGH HRTREKRLST PNQSPLSIRG 540
SLFSARRSSR TSLFSFKGRG RDLGSETEFA DDEHSIFGDN ESRRGSLFVP HRPRERRSSN 600
ISQASRSPPV LPVNGKMHSA VDCNGVVSLV DGPSALMLPN GQLLPEVIID KATSDDSGTT 660
NQMRKKRLSS SYFLSEDMLN DPHLRQRAMS RASILTNTVE ELEESRQKCP PWWYRFAHTF 720
LIWNCSPYWI KFKKLIYFIV MDPFVDLAIT ICIVLNTLFM AMEHHPMTEE FKNVLAVGNL 780
IFTGIFAAEM VLKLIAMDPY EYFQVGWNIF DSLIVTLSLI ELFLADVEGL SVLRSFRLLR 840
VFKLAKSWPT LNMLIKIIGN SVGALGNLTL VLAIIVFIFA VVGMQLFGKS YKECVCKINV 900
DCKLPRWHMN DFFHSFLIVF RVLCGEWIET MWDCMEVAGQ TMCLIVYMMV MVIGNLVVLN 960
LFLALLLSSF SSDNLTAIEE DTDANNLQIA VARIKRGINY VKQTLREFIL KSFSKKPKGS 1020
KDTKRTADPN NKKENYISNR TLAEMSKDHN FLKEKDRISG YGSSLDKSFM DENDYQSFIH 1080
NPSLTVTVPI APGESDLEIM NTEELSSDSD SDYSKEKRNR SSSSECSTVD NPLPGEEEAE 1140
AEPVNADEPE ACFTDGCVRR FPCCQVNVDS GKGKVWWTIR KTCYRIVEHS WFESFIVLMI 1200
LLSSGALAFE DIYIEKKKTI KIILEYADKI FTYIFILEML LKWVAYGYKT YFTNAWCWLD 1260
FLIVDVSLVT LVANTLGYSD LGPIKSLRTL RALRPLRALS RFEGMRVVVN ALIGAIPSIM 1320
NVLLVCLIFW LIFSIMGVNL FAGKFYECVN TTDGSRFPTS QVANRSECFA LMNVSGNVRW 1380
KNLKVNFDNV GLGYLSLLQV ATFKGWMDIM YAAVDSVNVN EQPKYEYSLY MYIYFVIFII 1440
FGSFFTLNLF IGVIIDNFNQ QKKKLGGQDI FMTEEQKKYY NAMKKLGSKK PQKPIPRPGN 1500
KFQGCIFDLV TNQAFDITIM VLICLNMVTM MVEKEGQTEY MDYVLHWINM VFIILFTGEC 1560
VLKLISLRHY YFTVGWNIFD FVVVILSIVG MFLAEMIEKY FVSPTLFRVI RLARIGRILR 1620
LIKGAKGIRT LLFALMMSLP ALFNIGLLLF LVMFIYAIFG MSNFAYVKKE AGINDMFNFE 1680
TFGNSMICLF QITTSAGWDG LLAPILNSAP PDCDPKKVHP GSSVEGDCGN PSVGIFYFVS 1740
YIIISFLVVV NMYIAVILEN FSVATEESTE PLSEDDFEMF YEVWEKFDPD ATQFIEFCKL 1800
SDFAAALDPP LLIAKPNKVQ LIAMDLPMVS GDRIHCLDIL FAFTKRVLGE GGEMDSLRSQ 1860
MEERFMSANP SKVSYEPITT TLKRKQEEVS ATIIQRAYRR YRLRQHVKNI SSIYIKDGDR 1920
DDDLPNKEDT VFDNVNENSS PEKTDVTAST ISPPSYDSVT KPDQEKYETD KTEKEDKEKD 1980
ESRK 1984 |
Gene Ontology | GO:0001518; C:voltage-gated sodium channel complex; IDA:RGD. GO:0031402; F:sodium ion binding; IDA:RGD. GO:0005248; F:voltage-gated sodium channel activity; IDA:RGD. GO:0048266; P:behavioral response to pain; IEA:Compara. GO:0006954; P:inflammatory response; IEA:Compara. GO:0009791; P:post-embryonic development; IEA:Compara. GO:0019228; P:regulation of action potential in neuron; IDA:RGD. GO:0009636; P:response to toxic substance; IEA:Compara. GO:0043179; P:rhythmic excitation; NAS:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |