| Tag | Content |
|---|
| CPLM ID | CPLM-001092 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A |
Protein Synonyms/Alias | |
Gene Name | Pde9a |
Gene Synonyms/Alias | Pde8b |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 114 | AFKINELKAEVANHL | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. |
Sequence Annotation | NP_BIND 251 255 cGMP (By similarity).
NP_BIND 451 452 cGMP (By similarity).
REGION 227 489 Catalytic (By similarity).
ACT_SITE 251 251 Proton donor (By similarity).
METAL 255 255 Divalent metal cation 1 (By similarity).
METAL 291 291 Divalent metal cation 1 (By similarity).
METAL 292 292 Divalent metal cation 1 (By similarity).
METAL 292 292 Divalent metal cation 2 (By similarity).
METAL 401 401 Divalent metal cation 1 (By similarity).
BINDING 292 292 cGMP (By similarity).
BINDING 401 401 cGMP (By similarity).
BINDING 423 423 cGMP (By similarity). |
Keyword | Alternative splicing; cGMP; Complete proteome; Hydrolase; Manganese; Metal-binding; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 534 AA |
Protein Sequence | MGAGSSSYRP KAIYLDIDGR IQKVVFSKYC NSSDIMDLFC IATGLPRNTT ISLLTTDDAM 60
VSIDPTMPAN SERTPYKVRP VAVKQVSERE ELIQGVLAQV AEQFSRAFKI NELKAEVANH 120
LAVLEKRVEL EGLKVVEIEK CKSDIKKMRE ELAARNSRTN CPCKYSFLDN KKLTPRRDVP 180
TYPKYLLSPE TIEALRKPTF DVWLWEPNEM LSCLEHMYHD LGLVRDFSIN PITLRRWLLC 240
VHDNYRNNPF HNFRHCFCVT QMMYSMVWLC GLQEKFSQMD ILVLMTAAIC HDLDHPGYNN 300
TYQINARTEL AVRYNDISPL ENHHCAIAFQ ILARPECNIF ASVPPEGFRQ IRQGMITLIL 360
ATDMARHAEI MDSFKEKMEN FDYSNEEHLT LLKMILIKCC DISNEVRPME VAEPWVDCLL 420
EEYFMQSDRE KSEGLPVAPF MDRDKVTKAT AQIGFIKFVL IPMFETVTKL FPVVEETMLR 480
PLWESREHYE ELKQLDDAMK ELQKKTESLT SGAPENTTEK NRDAKDSEGH SPPN 534 |
Gene Ontology | GO:0005829; C:cytosol; IEA:Compara. GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IDA:MGI. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0007165; P:signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |