UniProt Accession

 FOSL2_MOUSE; P47930; Q3UKX7; Q8C231 

Genbank Protein ID

 X83971; X83970; AK089371; AK145822; BC065131 

Genbank Nucleotide ID

 CAA58805.1; CAA58804.1; BAC40860.1; BAE26674.1; AAH65131.1 

Protein Name

 Fos-related antigen 2 

Protein Synonyms/Alias

 FRA-2 

Gene Name

 Fosl2 

Gene Synonyms/Alias

 Fra-2; Fra2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
104	LPRPGVIKTIGTTVG	acetylation	[1, 2]
222	AVGPVVVKQEPPEED	acetylation	[1, 2, 3]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity). 

Sequence Annotation

 DOMAIN 124 187 bZIP.
 REGION 126 128 Basic motif (By similarity).
 REGION 129 136 Leucine-zipper (By similarity).
 MOD_RES 120 120 Phosphoserine (By similarity).
 MOD_RES 200 200 Phosphoserine (By similarity).
 MOD_RES 230 230 Phosphoserine (By similarity).
 MOD_RES 320 320 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 326 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IDA:MGI.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0048146; P:positive regulation of fibroblast proliferation; IDA:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR004827; bZIP.
 IPR000837; Leuzip_Fos. 

Pfam

 PF00170; bZIP_1 

SMART

 SM00338; BRLZ 

PROSITE

 PS50217; BZIP
 PS00036; BZIP_BASIC 

PRINTS

 PR00042; LEUZIPPRFOS.