CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039563
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Pre-mRNA-splicing factor RBM22 
Protein Synonyms/Alias
  
Gene Name
 RBM22 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
163INDPVADKLLKRASTacetylation[1, 2, 3]
163INDPVADKLLKRASTubiquitination[4]
237AAEVAAEKSFNKLIVubiquitination[5]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; RNA-binding; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 371 AA 
Protein Sequence
MATSLGSNTY NRQNWEDADF PILCQTCLGE NPYIRMEREK SGLPIQVRDA GLSFKDDMPK 60
SDVNKEYYTQ NMEREISNSD GTRPVGMLGK ATSTSDMLLK LARTTPYYKR NRPHICSFWV 120
KGECKRGEEC PYRHEKPTDP DDPLADQNIK DRYYGINDPV ADKLLKRAST MPRLDPPEDK 180
TITTLYVGGL GDTITETDLR NHFYQFGEIR TITVVQRQQC AFIQFATRQA AEVAAEKSFN 240
KLIVNGRRLN VKWGRSQAAR GKEKEKDGTT DSGIKLEPVP GLPGALPPPP AAEEEASANY 300
FNLPPSGPPA VVNIALPPPP GIAPPPPPGF GPHMFHPMGP PPPFMRAPGP IHYPSQDPQR 360
MGAHAGKHSS P 371 
Gene Ontology
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom.
 IPR000571; Znf_CCCH. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM
 SM00356; ZnF_C3H1 
PROSITE
 PS50102; RRM
 PS50103; ZF_C3H1 
PRINTS